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ProteomicsLabel free quantitative proteomics reveals survival mechanisms developed by Hypertrophic chondrocytes under ER stress
Emerging evidence implicates ER stress caused by unfolded mutant proteins in chondrocytes as the underlying pathology of chondrodysplasias. ER stress is triggered in hypertrophic chondrocytes (HCs) in a mouse model (13del) of metaphyseal chondrodysplasia type Schmid (MCDS) caused by misfolded mutan...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-25 | PXD002125 | Pride
Metaphyseal chondrodysplasia type schmid Mitochondrial membrane polarity Glycolysis Calcium signaling 
ProteomicsProteomic landscape of murine intervertebral disc reveals mechanisms involved in homeostasis and disc structure maintenance
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a healthy disc. Using a quantitative proteomic approach, we analyzed methodically the differences existing between IVD genders, levels and ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD006671 | Pride
Mouse intervertebral disc Nucleus pulposus Annulus fibrosus Proteomic Homeostasis Structure maintenance 
ProteomicsSM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008784 | Pride
Mouse intervertebral disc Nucleus pulposus Lg/j and sm/j. Proteomic 
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