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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
TranscriptomicsTranscription profiling of livers from wild type, Clock mutant and Cry deficient C57BL/6 mice to characterize CLOCK-regulated circadian output genes.
Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined.
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-454 | biostudies-arrayexpress
ProteomicsImpact of P-glycoprotein on intracellular drug concentration in peripheral blood mononuclear cells and K562 cells
P-gp protein expression levels were evaluated in PBMC and lymphocyte with or without induction using TMT-10 plex procedure
ORGANISM(S): Homo Sapiens (human) 
2023-04-18 | PXD033283 | JPOST Repository
ProteomicsTMT-16plex analysis of 25 individual human liver microsome and cytosol
Comprehensive proteomic analysis for human liver microsome and human liver cytosol from 25 individual donors focusing on drug metabolising enzymes with relative quantification with TMTpro.
ORGANISM(S): Homo Sapiens (human) 
2023-11-09 | PXD038055 | JPOST Repository
UnknownPhylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers.
Not available
S-EPMC4281788 | biostudies-literature
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