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TranscriptomicsTranscription profiling of striatum from 12 weeks-old R6/2 mice and control mice (set 2)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 mice and control mice (set 1)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9803 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of striatal samples from 4 CHL2 Q150/Q150 mutant mice and 4 age-matched wild-type mice to investigate the study of huntingtin toxicity and its remedy in model systems.
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-04-10 | E-GEOD-10202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 3- and 18-month-old Q92 vs. control animals
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7958 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 months-old Hdh4/Q80 mice and control mice.
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9375 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 vs. control animals
This SuperSeries is composed of the following subset Series:; GSE9803: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 1); GSE9804: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 2) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9857 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatal samples from wildtype, Hdh/Q80 animals
This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 ...
ORGANISM(S): Mus musculus 
2008-05-21 | E-GEOD-10263 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat striatal neuron cultures infected with TRE-Htt-N853 - Huntingtons Disease in vitro model
Primary neuron model of Huntington's Disease. 2 treatment groups: A) Infected 4 weeks prior with TRE-Htt-N853-18Q-expressing recombinant lentivirus, B) Infected 4 weeks prior with TRE-Htt-N853-82Q-expressing recombinant lentivirus Experiment Overall Design: Primary neurons samples infected with TRE-...
ORGANISM(S): Rattus norvegicus 
2008-10-25 | E-GEOD-12481 | biostudies-arrayexpress
TranscriptomicsLymphocyte gene expression data from moderate stage HD patients and controls
Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a lar...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-8762 | biostudies-arrayexpress
TranscriptomicsGene expression from primary brain cell cultures and RNA mixtures.
Gene expression from primary neuronal, astrocytic, oligodendrocytic and microglial cultures, as well as from RNA mixtures thereof. Keywords: Primary cell cultures Primary neuronal, astrocytic, oligodendrocytic and microglial cultures (4 biological replicates of each), as well as RNA mixtures thereo...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-19380 | biostudies-arrayexpress
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