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TranscriptomicsTranscription profiling of mouse model of endometrioid ovarian adenocarcinomas by conditional inactivation of the PTEN and APC genes
Fifty million plaque-forming units of AdCre was injected into the right ovarian bursal cavity of 56- 70 day old female mice. Mice were euthanized 63 days later to obtain ovary tumors and normal ovary tissue. Seven individual ovarian tumors and 4 individual normal ovary samples were each assayed on...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5987 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ovarian tumors and normal ovaries
99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell carcinomas) and 4 individual normal ovary samples, each assayed on an Affymetrix HG_U133A array Experiment Overall Design: 99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell c...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pre-invasive and invasive cervical squamous cell carcinomas and normal cervical epithelia
10 normal squamous cervical epitheilia samples, 7 high grade squamous intraepithelial lesions, and 21 invasive squamous cell carcinomas of the cervix samples were obtained using laser capture miicrodissection. Two rounds of T7-based linear RNA amplification using the Arcturus RiboAmp kit were perfo...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7803 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thyroid cells exposed to INF-gamma and IL1-beta
Normal primary thyroid cells were incubated with , 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A a...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-5054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SW480 cells stably expressing miRNA34
SW480 were stably transfected with an episomal plasmid expressing GFP and miRNA34 from a bidirectional doxycyclin regulatable promoter (Bornkamm et al Nucleic Acids Res. 2005 Sep 7;33(16)). Polyclonal cell lines were obtained by selection with Hygromycin at 350ug/ml for 10 days. The cell llnes ident...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7678 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 lung adenocarcinoma cell line time Course of TGF-beta treatment
Time Course of TGF-beta treatment of A549 lung adenocarcinoma cell line on Affymetrix HG_U133_plus_2 arrays; triplicate experiments. The goal of the experiment is to profile temporal gene expression changes during TGF-beta-induced epithelial-mesenchymal transition (EMT). During EMT cancer cells lo...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-17708 | biostudies-arrayexpress
TranscriptomicsEffects of Lipocalin 2 (Lcn2), iron, and the bacterial siderophore Enterobactin on A549 respiratory cell gene expression
Iron is essential for many cellular processes and is required by bacteria for replication. To acquire iron from the host, pathogenic Gram-negative bacteria secrete siderophores, including Enterobactin (Ent). However, Ent is bound by the host protein Lipocalin 2 (Lcn2), preventing bacterial reuptake ...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54962 | biostudies-arrayexpress
TranscriptomicsGSK3B shRNA in Panc-1 xenografts
The Panc-1 human pancreatic cancer line (ATCC) was constructed to stably express control or GSK3B shRNA. Control or GSK3B shRNA expressing Panc-1 cells were implanted subcutaneously into the flanks of 3-5 week old, female, athymic nude mice. Tumors were grown to at least 250mm3. Tumor tissue was mic...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-35351 | biostudies-arrayexpress
TranscriptomicsOviductal vs. ovarian epithelial transformation yields very different tumor phenotypes in Apc fl/fl;Pten fl/fl mice
We treated 6-8 week old mice that had floxed alleles of both Apc and Pten (for both alleles in each case) that also carry an Ovgp1-iCre-ERT2 transgene, with one of two treatments; a third group received neither treatment. The Ovgp1-iCre-ERT2 expresses Cre recombinase fused to a tamoxifen-inducible f...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-80085 | biostudies-arrayexpress
TranscriptomicsshRNA knockdown of ZMIZ1 in human T-cell Acute Lymphoblastic Leukemia cell line CEM
Human T-cell Acute lymphoblastic Leukemia cell line CEM was transfected with either shRNA against ZMIZ1 or scrambled shRNA. Four (non-paired) biological replicates of each condition had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. A supplementary Excel workb...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-32523 | biostudies-arrayexpress
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