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TranscriptomicsDefinition, conservation and epigenetics of housekeeping and tissue-enriched genes
Housekeeping genes (HKG) are constitutively expressed in all tissues while tissue-enriched genes (TEG) are expressed at a much higher level in a single tissue type than in others. HKGs serve as valuable experimental controls in gene and protein expression experiments, while TEGs tend to represent d...
ORGANISM(S): Homo sapiens 
2009-06-10 | E-GEOD-16546 | biostudies-arrayexpress
TranscriptomicsDifferential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues
Alternative pre-messenger RNA splicing impacts development, physiology, and disease, but its regulation in humans is not well understood, partially due to the limited scale to which the expression of specific splicing events has been measured. We generated the first genome-scale expression compendi...
ORGANISM(S): Homo sapiens 
2008-08-15 | E-GEOD-11863 | biostudies-arrayexpress
TranscriptomicsExon and junction microarrays detect widespread mouse strain- and sex-bias expression differences
71 liver RNA samples from three mouse strains - DBA/2J, C57BL/6J and C3H/HeJ - were profiled using a custom-designed microarray monitoring exon and exon-junction expression of 1,020 genes representing 9,406 exons. Gene expression was calculated via two different methods, using the 3'-most exon prob...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10736 | biostudies-arrayexpress
TranscriptomicsAgilent Mouse liver gene expression profiling of Cross B6/J x A/J
Mapping the genetic architecture of RNA transcript abundances has potential for revealing molecular mechanisms underlying complex traits like disease. Gene expression microarrays allow monitoring genetic control on a whole transcriptome level, but validity and reproducibility of microarray data is a...
ORGANISM(S): Mus musculus 
2011-02-02 | E-GEOD-20901 | biostudies-arrayexpress
TranscriptomicsAffymetrix Mouse liver gene expression profiling of Cross B6/J x A/J
Summary Mapping the genetic architecture of RNA transcript abundances has potential for revealing molecular mechanisms underlying complex traits like disease. Gene expression microarrays allow monitoring genetic control on a whole transcriptome level, but validity and reproducibility of microarray d...
ORGANISM(S): Mus musculus 
2011-02-02 | E-GEOD-20902 | biostudies-arrayexpress
TranscriptomicsIdentification of biomarkers for tumor endothelial cell proliferation through gene expression profiling
Extensive efforts are underway to identify anti-angiogenic therapies for the treatment of human cancers. Many proposed therapeutics target vascular endothelial cell growth factor (VEGF) or the kinase insert domain receptor (KDR/VEGFR-2/FLK-1), the mitogenic VEGF receptor tyrosine kinase expressed by...
ORGANISM(S): Homo sapiens 
2005-09-13 | E-GEOD-3299 | biostudies-arrayexpress
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
UnknownGlobal mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.
Not available
S-EPMC9763654 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
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