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TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following targeted depletion of non metastatic 2 (NME2/NM23 H2)
Non-metastatic 2 (NME2) is an established metastases suppressor in multiple human cancer types. However, the molecular mechanisms of NME2 action remain insufficiently resolved. We recently validated the transcription regulatory activity of NME2 with respect to control of proto-oncogene c-MYC express...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18182 | biostudies-arrayexpress
TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following induction of non metastatic 2 (NME2/NM23 H2)
It is widely believed that reorganization of nucleosomes result in availability of binding sites that engage transcription factors during eukaryotic gene regulation. Recent findings, on the other hand, suggest that transcription factors induced as a result of physiological perturbations directly (or...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40194 | biostudies-arrayexpress
TranscriptomicsTelomerase inhibitor TMPyP4 induced widespread gene expression
The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes, analyzed across different cell-lines, was investigated Keywords: Comparative gene-expression profiling Cells were treated with TMPyP4 for 48 hours before RNA isolation. Untreated cells were...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-9710 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in A549 cells before/after NME2 induction
Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40363 | biostudies-arrayexpress
GenomicsGenome-wide maps of NME2 in A549 lung adenocarcinoma cells.
It is widely believed that reorganization of nucleosomes result in availability of transcription factor (TF) binding sites for eukaryotic gene regulation. Recent findings also show TFs induced during physiological perturbations can alter nucleosome occupancy to facilitate DNA binding. Although, thes...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40300 | biostudies-arrayexpress
UnknownAKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma.
Not available
S-EPMC10820337 | biostudies-literature
GenomicsHigh resolution methylome map of rat reveals role of intragenic DNA methylation in identifying coding region and alternative splice site.
We report the application of next generation sequencing technology for high-throughput profiling of cytosine methylation in adult rat liver tissue. To investigate the role of intragenic methylation, we generated the first high resolution methylation map of rat liver tissue and compared it with the p...
ORGANISM(S): Rattus norvegicus 
2011-12-20 | E-GEOD-31571 | biostudies-arrayexpress
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