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Mitotic catastrophe (MC) is an important mechanism to remove cells that become polyploid or aneuploid, as an oncosuppressive mechanism. Previous studies have demonstrated that the activation and catalytic function of caspase-2 is a key step in MC, to trigger apoptosis and/or cell cycle arrest of suc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017866 | Pride
Autophagy is a highly conserved lysosomal degrative pathway important for maintaining cellular homeostasis. Much of our current knowledge of autophagy is focused on the initiation steps with the later steps, particularly lysosomal fusion leading to autolysosome formation and the subsequent role of l...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-02-15 | PXD016675 | Pride
NEDD4-2 is an E3 ubiquitin ligase involved in the regulation of several membrane proteins. This project was designed to identify new NEDD4-2-regulated substrates in the mouse cortical collecting duct cell line.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD063842 | Pride
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