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GenomicsConserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease
Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during ne...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65159 | biostudies-arrayexpress
GenomicsMatrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
PRJNA545478 | ENA
GenomicsWhole genome mapping of STAT3 binding sites in the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the effect of the transcription factor STAT3 in the two major subtypes of diffuse large B cell lymphoma (DLBCL). STAT3 is a signal transducer that, when dysregulated, becomes a powerful oncogene found in many human cancers, including DLBCL. DLBCL is the most c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50723 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the transcriptome differences between the two major subtypes of diffuse large B cell lymphoma (DLBCL). DLBCL is the most common form of non-Hodgkin’s lymphoma and has two major subtypes: germinal center B-cell-like (GCB) and activated B-cell-like (ABC). When c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50721 | biostudies-arrayexpress
UnknownA common pattern of DNase I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization.
Not available
S-EPMC6071632 | biostudies-literature
UnknownAn atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development.
Not available
S-EPMC5170597 | biostudies-literature
UnknownDART-Eval: A Comprehensive DNA Language Model Evaluation Benchmark on Regulatory DNA.
Not available
S-EPMC12340898 | biostudies-literature
ProteomicsA genome-wide atlas of co-essential modules assigns function to uncharacterized genes
A central remaining question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into ‘co-essential’ pathways, but this approach has been limited by ubiquitous false positives. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023558 | Pride
Ip-ms Tmem189 C15orf57 
TranscriptomicsATAC-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). WNT signalling sustains both NMP expansion and PM differentiation, but the mechanism by which it distinguishes between these a...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9776 | biostudies-arrayexpress
UnknownThe chromatin organization of a chlorarachniophyte nucleomorph genome.
Not available
S-EPMC8887012 | biostudies-literature
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