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TranscriptomicsComplete hematologic response of early-T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
Notch pathway antagonists such as gamma-secretase inhibitors (GSI) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early-T-cell progenitor acute lymphoblastic leukemia (ETP-ALL) who achieved a complete...
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-71414 | biostudies-arrayexpress
UnknownArginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.
Not available
S-EPMC3839414 | biostudies-literature
TranscriptomicsMethylation profiles of esophageal squamous cell carcinoma patients and cancer-free individual in Taiwan.
Genome wide DNA methylation profiling of tumor and normal samples with esophageal squamous cell carcinoma patients. The Illumina GolodenGate methylation cancer panel I was used to obtain DNA methylation profiles across approximately 1,505 CpGs in esophageal squemous cell carcinoma samples. Samples i...
ORGANISM(S): Homo sapiens 
2014-09-11 | E-GEOD-51287 | biostudies-arrayexpress
UnknownA Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes.
Not available
S-EPMC9492650 | biostudies-literature
TranscriptomicsGenome-wide Expression Profiles of Subchondral Bone in Osteoarthritis
To date, all of the prior osteoarthritic microarray studies in human tissue have focused on the overlying articular cartilage, meniscus, or synovium but not the underlying subchondral bone. In our previous study, our group developed a methodology for high quality RNA isolation from site-matched cart...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51588 | biostudies-arrayexpress
UnknownTemporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19.
Not available
S-EPMC8961941 | biostudies-literature
TranscriptomicsRegulation of microRNA Expression and Abundance during Lymphopoiesis
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We used deep-sequencing to characterize the microRNome from most developing lymphocytes, various hematopoietic cell lineages, and representative m...
ORGANISM(S): Mus musculus 
2010-06-07 | E-GEOD-21630 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells (HSCs), progenitor cells (HPCs), and granulocytes somatic cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer
Since the creation of Dolly, the first sheep cloned via somatic cell nuclear transfer (SCNT), in 1997, more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1-5%) is that the clones are likely derived from adult stem...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5677 | biostudies-arrayexpress
ProteomicsMutant glucocerebrosidase impairs -synuclein degradation by blockade of chaperone-mediated autophagy
The most common genetic risk factors for Parkinson’s disease (PD) are a set of heterozygous mutant (MT) alleles of the GBA1 gene that encodes -glucocerebrosidase (GCase), an enzyme that is normally trafficked from the endoplasmic reticulum and Golgi apparatus to the lysosomal lumen. We examined isol...
ORGANISM(S): Homo sapiens (Human) 
2022-02-03 | PXD028656 | Pride
Brain Gba Cma Itraq 
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
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