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UnknownEfficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform.
Directed evolution has long been a key strategy to generate enzymes with desired properties like high selectivity, but experimental barriers and analytical costs of screening enormous mutant libraries have limited such efforts. Here, we describe an ultrahigh-throughput dual-channel microfluidic drop...
S-EPMC5847605 | biostudies-literature
UnknownA tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring.
Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-resembling models than animal models for disease study and drug discovery. Particularly, the Blood-Brain-Barrier-on-a-chip (BBB-oC) has emerged as a promising tool to investigate several neurological disorders ...
S-EPMC10401069 | biostudies-literature
UnknownMachine learning-based cytokine microarray digital immunoassay analysis.
Serial measurement of a large panel of protein biomarkers near the bedside could provide a promising pathway to transform the critical care of acutely ill patients. However, attaining the combination of high sensitivity and multiplexity with a short assay turnaround poses a formidable technological ...
S-EPMC7896497 | biostudies-literature
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