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ProteomicsGlycosylation Profiling of Neoplastic Biomarker Alpha Fetoprotein Through Intact Mass Protein Analysis
Alpha fetoprotein (AFP) is a circulating cancer biomarker implicated in multiple neoplastic malignancies, including hepatocellular carcinoma (HCC). AFP glycoforms with core fucosylation structure (AFP-L3) are used clinically as a biomarker, to predict risk of developing HCC and to monitor its recur...
ORGANISM(S): Homo sapiens (Human) 
2023-01-11 | PXD038606 | Pride
Afp-l3 proteforms Core fucose Fucosylation High-resolution mass spectrometry Intact protein analysis 
ProteomicsGlycosylation Profiling of Neoplastic Biomarker Alpha Fetoprotein Through Intact Mass Protein Analysis
Glycosylation is an important post-translational modification (PTM) mechanism of proteins, that modulates protein function. Measurement of clinically adopted cancer protein biomarkers is commonly performed using affinity-based techniques, which often suffer from poor specificity and inability to dis...
ORGANISM(S): Homo sapiens (Human) 
2023-01-11 | PXD038602 | Pride
Intact proteins Hepatocellular carcinoma 
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