Sort   by:  
 Page size 
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
TranscriptomicsRapidly induced fucosylation of intestinal epithelium sustains host-commensal symbiosis during sickness.
Systemic infection induces conserved physiological responses that include both resistance and ‘tolerance of infection’ mechanisms. Among these responses, temporary anorexia associated with an infection is often beneficial. It poses, however, a problem for the trillions of microbes residing in the ga...
ORGANISM(S): mouse gut metagenome 
2014-10-24 | E-GEOD-60874 | biostudies-arrayexpress
ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: HLA-DRB1 Interactomes
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038068 | Pride
Fucosylation Melanoma Interactome Hla-drb1 Immunotherapy 
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
GenomicsWidespread multi-targeted therapy resistance via drug-induced secretome fucosylation
Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation
PRJNA672332 | ENA
ProteomicsWidespread multi-targeted therapy resistance via drug-induced secretome fucosylation
Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post translational cancer hallmark and the consequences thereof remain elusive. Here we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted the...
ORGANISM(S): Homo sapiens (Human) 
2023-04-05 | PXD022240 | Pride
N-linked glycosylation Resistance Fucosylation Targeted therapy Secretome 
ProteomicsInflammatory Signaling is Regulated by Fucosylation in Metastatic Breast Cancer Cells
N-linked glycosylation results in a large branched tree-like sugar structure composed of several types of individual carbohydrates being attached to a protein. Fucosylation is one specific type of glycosylation that is defined by the addition of α-L-fucose to a carrier protein. Although fucosylation...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD021413 | Pride
Fucosylation  n-glycsoylation  breast cancer Nf-κb Metastasis 
ProteomicsCancer-associated Notch receptor variants lead to O-fucosylation defects that can deregulate Notch signaling
NOTCH1 is a transmembrane receptor that initiates the Notch signaling pathway involved in embryonic development and maintenance of adult tissue homeostasis. The extracellular part of NOTCH1 is composed largely of EGF-like domains (EGFs) many of which can be O-fucosylated by protein O-fucosyltransfer...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD036345 | Pride
O-fucosylation Egf repeat Cancer Notch Pofut1 
Sort   by:  
 Page size