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ProteomicsAnalysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development
NOTCH1 (N1) is a transmembrane receptor interacting with membrane-tethered ligands on opposing cells that mediate the direct cell-cell interaction necessary for many cell fate decisions. Protein O-fucosyltransferase 1 (POFUT1) adds O-fucose to Epidermal Growth Factor (EGF)-like repeats in the NOTCH ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD050256 | Pride
Notch1 Mass spectrometry O-fucose Pofut1 
GenomicsEndothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis
Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis
PRJNA1078377 | ENA
TranscriptomicsComparison of Wild type and Pofut1-deleted skeletal muscle
Pofut1 is an essential gene that glycosylates proteins containing EGF-like repeats, including Notch Receptors (NotchRs).  Work in mice and in Drosophila has shown that O-fucosylation by Pofut1 is required for NotchR ligands to bind to and activate NotchRs.  As such, Pofut1 deletion in skeletal myofi...
ORGANISM(S): Mus musculus 
2017-03-27 | GSE80145 | GEO
TranscriptomicsComparison of Wild type and Pofut1-deleted skeletal muscle in young and old mice
Pofut1 is an essential gene that glycosylates proteins containing EGF-like repeats, including Notch Receptors (NotchRs).  Work in mice and in Drosophila has shown that O-fucosylation by Pofut1 is required for NotchR ligands to bind to and activate NotchRs.  As such, Pofut1 deletion in skeletal myofi...
ORGANISM(S): Mus musculus 
2017-03-27 | GSE94768 | GEO
TranscriptomicsEndothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis
Background & Aims: NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chronic liver diseases. POFUT1 is an essential regulator of NOTCH signaling. Here, we investigated the role of LSECs-expressed POFUT1 in liver fibrosis. Methods: Endot...
ORGANISM(S): Mus 
2024-12-18 | GSE256179 | GEO
TranscriptomicsPOFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma
Protein O - Fucosyltransferase 1 (POFUT1) is a significantly different gene in gliomas. The analysis of the The Cancer Genome Atlas Program (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and clinical samples found that POFUT1 was highly expressed in tumor tissue (p < 0.01). Glioma patients ...
ORGANISM(S): Homo sapiens 
2026-03-31 | GSE316535 | GEO
GenomicsPOFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma
POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma
PRJNA1403273 | ENA
TranscriptomicsRole of loss of Pofut1 expression on self-renewal and differentiation of adult neural progenitor cells
Reduced NotchR signaling has been implicated in the reduced division and differentiation of stem cells in a number of tissues. The Protein-O-fucosyltransferase 1 gene (Pofut1) encodes a glycosyltransferase that O-fucosylates EGF-repeat-containing proteins, including Notch Receptors (NotchRs), and ab...
ORGANISM(S): Mus musculus 
2018-04-16 | GSE97610 | GEO
UnknownPOFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
Not available
S-EPMC6266312 | biostudies-literature
UnknownFunctional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
Not available
S-EPMC7352195 | biostudies-literature
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