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TranscriptomicsRequirement for the Mediator kinase module for activation of super-enhancer associated genes in colon cancer cells
RNA sequencing of HCT116 colon cancer cells following single and combined depletions of Mediator kinase module subunits CDK8, CDK19, MED12, MED13 and MED13L and the BET family protein BRD4. The results provide insight into the shared and specific functions of kinase module subunits and BRD4 in regul...
ORGANISM(S): Homo sapiens 
2018-04-02 | E-MTAB-5873 | biostudies-arrayexpress
TranscriptomicsCdk8, Cyclin C, Med12 or Med13 depletion effect on gene expression in Drosophila S2 cells
Expression profiling following depletion of Mediator Cdk8 module subunits Cdk8, Cyclin C (CycC), Med12 and Med13 72 hours after dsRNA treatment of Drosophila melanogaster S2 cells. Results provide insight into the role of individual Cdk8 module subunits in regulation of transcription. 22 samples. 2 ...
ORGANISM(S): Drosophila melanogaster 
2014-04-29 | E-GEOD-52343 | biostudies-arrayexpress
TranscriptomicsWhole-genome oxidative bisulfite sequencing and data processing of mouse intestinal stem cells with old and young mitochondria
The intent of the study was to profile the methylome and hydroxymethylome in intestinal stem cells with young mitochondria or old old mitochdondria, to ascertain the potential role of mitochondrial age specific influence on epigenetic regulation of ISCs.
ORGANISM(S): Mus musculus 
2025-05-07 | E-MTAB-15119 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Dm-aKG treated intestinal stem cells (ISCs) and controls
The object of this study was to investigate how aKG impacts mouse intestinal stem cell (ISCs) function and fate decisions in vivo. Mice were treated for 7 days with twice daily aKG IP injections after which ISCs were FACS sorted and transcriptomically anayzled. This revealed a striking set of secret...
ORGANISM(S): Mus musculus 
2025-05-02 | E-MTAB-15105 | biostudies-arrayexpress
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