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ProteomicsMAPPING HEART FIBROSIS: INTEGRATIVE PHOSPHOPROTEOMIC PROFILING OF CLINICAL SAMPLES, ANIMAL AND ORGAN-ON-A-CHIP MODELS
Precision mass spectrometry, animal models and organ-on-a-chip (OOC) systems have emerged as promising experimental strategies to study the molecular mechanisms governing human biology and disease, including the molecular basis of cardiovascular disorders like fibrosis where access to patient sample...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-12 | PXD011107 | Pride
Human Mouse model Heart Hypertrophy Phosphoproteomic Organ-on-a-chip Fibrosis 
ProteomicsIntegrative proteomic and phosphoproteomics analysis of human ischemic and dilated cardiomyopathic explant tissues identifies etiology-specific phosphorylation patterns and signaling pathways
Myocardial tissue samples were explanted from the explanted left ventricle of heart failure patients with DCM (n=4), left ventricular infarct, peri-, and non-infarct regions of HF patients with ICM (n=4) at the time of their heart transplant surgeries, and the left ventricle of age- and sex-matched ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD012664 | Pride
Heart Phosphoproteomic Cardiac tissue Signaling Qe hf 
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
OtherPhosphoproteomic Network Analysis in the Sea Urchin Strongylocentrotus purpuratus Reveals New Candidates in Egg Activation.
Data from ProteomeXchange, PXD ID: PXD002239. Experiment: HILIC_hcd_seaurchin_UN3, file: HILIC_hcd_seaurchin_UN3_F14.mzml. Published as part of Proteomics. 2015 Jul 29 . From the Abstract: {{i}} Fertilization triggers a dynamic symphony of molecular transformations induced by a rapid rise in intrac...
ORGANISM(S): Strongylocentrotus_purpuratus 
GPM32310023141 | GPMDB
Resource Reanalysis 
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