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TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (sequencing)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42397 | biostudies-arrayexpress
TranscriptomicsGenome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flavopiridol, and tracked Pol II kinetically using GRO...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-48895 | biostudies-arrayexpress
TranscriptomicsPrecise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing
Transcription regulation occurs frequently through promoter-associated pausing of RNA polymerase II (Pol II). We developed a Precision nuclear Run-On and sequencing assay (PRO-seq) to map the genome-wide distribution of transcriptionally-engaged Pol II at base-pair resolution. Pol II accumulates imm...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-42117 | biostudies-arrayexpress
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