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ProteomicsAnalysing the Mechanism of Mitochondrial Oxidation-induced Cell Death Using a Multifunctional Iridium(III) Photosensitiser
Mitochondrial oxidation-induced cell death, a physiological process triggered by various cancer therapeutics to induce oxidative stress on tumours, has been challenging to investigate owing to the difficulties in generating mitochondria-specific oxidative stress and monitoring mitochondrial response...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD022163 | Pride
Photosensitiser Iridium(iii) complex Mitochondrial oxidation-induced cell death Photo-crosslinking Depolarisation 
ProteomicsOxygen-confined photooxidation represents a novel form of oxidative protein damage
Oxidative modifications can disrupt protein folds and functions, and are strongly associated with human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Yet, it remains unclear wheth...
ORGANISM(S): Homo Sapiens (human) Escherichia Coli 
2024-11-27 | PXD056895 | JPOST Repository
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