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TranscriptomicsRRBS (DNA methylation) analysis of CD4+ CD8+ and CD4-CD8- fractions of PBMC cells collected from 7 case children, who were positive for type 1 diabetes specific autoantibodies, and their matched controls, sampled at 3, 6, 12, 18, 24, and 36 months of age
10.1007/s00125-022-05657-x
ORGANISM(S): Homo sapiens 
2022-02-14 | E-MTAB-11088 | biostudies-arrayexpress
TranscriptomicsPreprocessed reduced representation bisulfite sequencing (RRBS) data from 173 human umbilical cord blood samples, collected for a study on associations between perinatal DNA methylation marks and progression to type 1 diabetes by age 15
The samples were collected from the participants of the Finnish Diabetes Prediction and Prevention (DIPP) Study, born between 1995 and 2006. DIPP is a prospective follow-up cohort of children with a moderate or high risk of type 1 diabetes, based on the HLA-DR-DQ genotype. Islet cell autoantibodies ...
ORGANISM(S): Homo sapiens 
2022-06-06 | E-MTAB-10530 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression kinetics of children with Type 1 diabetes (T1D) -associated autoantibodies or progression towards clinical T1D, compared to healthy matched controls .
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 357 peripheral blood...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-43488 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls I
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 63 peripheral blood ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30208 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls II
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 58 peripheral blood ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30209 | biostudies-arrayexpress
TranscriptomicsGenome-wide espression kinetics of children progressing to clinical Type 1 diabetes (T1D).
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 247 peripheral blood...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30210 | biostudies-arrayexpress
TranscriptomicsGene expression changes during Type 1 diabetes pathogenesis
This SuperSeries is composed of the SubSeries listed below. Due to privacy concerns, the SNP data is not available with unrestricted access. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30211 | biostudies-arrayexpress
ProteomicsD15_LF
RAW files Case5T and Control5T (CS and CO) represent D15 and Control-15 and are marked by their visit number. These are label free analyses of depleted serum samples conducted with an Orbitrap Velos- Proxeon capillary LC combination. CID fragmentation was used. The samples were analyzed in quadrupli...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078761 | MassIVE
ProteomicsD7_iTRAQ
D7_1 and D7_2 are 8 plex iTRAQ analyses of depleted serum samples. The files are mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078753 | MassIVE
ProteomicsD9_iTRAQ
D1_1 and D1_2 are 8 plex iTRAQ analyses of depleted serum samples. The files are mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078755 | MassIVE
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