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TranscriptomicsLong-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients
Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS). In tauopathies and polyglutamine diseases a mutant form of Ubiquitin B, UBB+1, accumulates in disease-specific aggregates. UBB+1 mRNA is generated at low levels in vivo during transcriptio...
ORGANISM(S): Mus musculus 
2012-06-12 | E-GEOD-13691 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and proteomic profiling of mouse hippocampus
We have correlated transciptomics, proteomics and toponomics analyses of hippocampus tissue of inbred C57/BL6 mice to analyse the interrelationship of expressed genes and proteins at different levels of organization. We find that transcriptome and proteome levels of function are highly conserved bet...
ORGANISM(S): Mus musculus 
2008-06-19 | E-GEOD-8239 | biostudies-arrayexpress
TranscriptomicsSynergism between curdlan and GM-CSF in mouse dendritic cells
A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity for an efficient defence against distinct pathogens. For example, cross talk of TLR and c-type lectin signalling effectively shapes distinct gene expression patterns by integrating the sign...
ORGANISM(S): Mus musculus 
2011-10-14 | E-GEOD-32986 | biostudies-arrayexpress
ModelsMorpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
Morpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
2020-11-27 | 759 | FAIRDOMHub
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