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MetabolomicsMechanistic Insights into Lactic Acid Bacteria-Driven Biotransformation of Undaria pinnatifida: Ecological Dominance, Metabolic Reprogramming, and Quality Formation
Undaria pinnatifida, a representative brown macroalga, is limited in high-value food applications due to its dense cell wall structure, pronounced marine odor, and inefficient conventional processing. In this study, a controlled fermentation strategy was established using different lactic acid bacte...
2026-05-20 | MTBLS14540 | MetaboLights
MetabolomicsLimosilactobacillus reuteri with indole-3-lactic acid-producing capacity protects against atherosclerosis by fortifying the gut-vascular barrier

Introduction: The gut microbiota and its metabolites are implicated in atherosclerosis, but the specific effector molecules and their pathophysiological significance remain unclear.

Objectives: This study aimed to identify key atheroprotective microbial metabolites and to elucidate the mech...

2026-01-31 | MTBLS13620 | MetaboLights
MetabolomicsLacto-N-tetraose mediates indole-3-lactic acid production by Bifidobacterium longum subsp. infantis to alleviate enterotoxigenic Escherichia coli-induced diarrhea in infants

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea and poses a threat to infant health. Current treatments for ETEC infection primarily rely on antibiotics，which face limitations due to resistance and side effect. In this cross-sectional study, we analyzed fecal met...

2025-08-24 | MTBLS12886 | MetaboLights
MetabolomicsBacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis

The gut microbiota plays a crucial role in the onset and progression of inflammatory bowel disease (IBD). β-glucan (BG), a soluble dietary fiber widely present in oats, barley, fungi, yeast and some bacteria, has multiple bioactive properties such as mitigating intestinal inflammation; however, t...

2024-02-12 | MTBLS8950 | MetaboLights
TranscriptomicsLactic acidosis triggers starvation response with distinct metabolic profiles
[1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for different length of time. We used microarrays to examine the genomic programs of cells incubated under lactic acidosis for different length of time [2] Metabolic profiling: MCF7 cells were exposed to control condition, ...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-19123 | biostudies-arrayexpress
TranscriptomicsThe genomic analysis of the interaction between the lactic acidosis and hypoxia response
Lactic acidosis and hypoxia are two prominent tumor microenvironmental stresses that are both known to exert important influences on gene expression and phenotypes of cancer cells. But very little is known about the cross-talk and interaction between these two stresses. We performed gene expression ...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-29406 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HMEC exposed to lactic acidosis and hypoxia
Human Mammalian Epithelial Cells (HMEC) were exposed to different environmental stresses, including hypoxia, lactic acidosis, the combination of hypoxia and lactic acidosis, lactosis , as well as acidosis. We used microarrays to examine the genomic programs of cells incubated under different microen...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-9649 | biostudies-arrayexpress
TranscriptomicsExpression data from 4T1 cells cultured with 3mM glucose and 20mM lactic acid
Via aerobic glycolysis-Warnburg effect, cancer cells can convert 85-90% of glucose they acquire to lactic acid, which is thus ubiquitously abundant in solid tumor environment. We also observed that lactic acid effectively rescues cancer cells from glucose staration. In order to understand the biolog...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-25525 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and physiological responses of Bacillus cereus to organic and inorganic acid down-shocks
Comparative phenotype and transcriptome analyses were performed with Bacillus cereus ATCC 14579 exposed to acid down-shock to pH 5.5 set with different acidulants. When acidified with hydrochloric acid (HCl), growth was diminished, whereas 2 mM undissociated lactic acid (HL) or acetic acid (HAc) sto...
ORGANISM(S): Bacillus cereus 
2010-06-25 | E-GEOD-15140 | biostudies-arrayexpress
TranscriptomicsWhole genome transcriptional profiling of reconstructed human epidermis treated with 5% lactic acid compare to negative control as treated with water
Lactic acid is used to check skin sensitivity of human. However transcriptional profiling has not been done yet. This study was targeted to understand the transcriptional changes occur in human skin upon treatment with lactic acid.
ORGANISM(S): Homo sapiens 
2019-06-07 | E-MTAB-6935 | biostudies-arrayexpress
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