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TranscriptomicsA circadian gene expression atlas in mammals assayed by RNA-seq
To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an organ-...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-54651 | biostudies-arrayexpress
TranscriptomicsA circadian gene expression atlas in mammals assayed by microarray
To characterize the role of the circadian clock in mouse physiology and behavior, we used RNA-seq and DNA arrays to quantify the transcriptomes of 12 mouse organs over time. We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an organ-...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-54650 | biostudies-arrayexpress
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
TranscriptomicsHigh-throughput sequencing of mouse liver transcriptome.
Circadian profile of polyA RNA by RNA-Seq, collected from mouse liver at CT23, CT29, CT35, CT41, CT47, CT53, CT59, CT65. RNA from three livers pooled per time point. 8 wildtype samples with no replicates.
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-40190 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of mouse liver transcriptome in Clock mutant animals
Circadian profile of polyA RNA by RNA-Seq, collected from Clock?19 mouse liver at CT22, CT28, CT34, CT40. RNA from three livers pooled per time point. 4 Clock mutant samples with no replicates
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-41082 | biostudies-arrayexpress
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
TranscriptomicsIVT-seq reveals extreme bias in RNA-sequencing
Background RNA sequencing (RNA-seq) is a powerful technique for identifying and quantifying transcription and splicing events, both known and novel. However, given its recent development and the proliferation of library construction methods, understanding the bias it introduces is incomplete but cri...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-50445 | biostudies-arrayexpress
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