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GenomicsProfiling Genome-wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells
We have engineered the chromatin-modifying apparatus and formulated a novel technology, termed Clickable Chromatin Enrichment with parallel DNA sequencing (CliEn-seq), to probe genome-wide chromatin modification within living cells. Examine (E)-hex-2-en-5-ynylation mediated by engineered G9a Y1154A ...
ORGANISM(S): Homo sapiens 
2013-03-04 | E-GEOD-42792 | biostudies-arrayexpress
TranscriptomicsTimEX from human embryonic stem cells, mesenchymal stem cells, and erythroid cells
The organization of mammalian DNA replication is poorly understood. We have produced genome-wide high-resolution dynamic maps of the timing of replication in human erythroid, mesenchymal and embryonic stem cells using TimEX, a method that relies on gaussian convolution of massive, highly redundant d...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-18679 | biostudies-arrayexpress
GenomicsHigh Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells
H1 linker histones facilitate higher order chromatin folding and are essential for mammalian development. To achieve high resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that the N-terminally tagged H1 proteins are functi...
ORGANISM(S): Mus musculus 
2013-04-29 | E-GEOD-46134 | biostudies-arrayexpress
TranscriptomicsReprogramming of Human Fibroblasts into Hematopoietic Progenitors by Fusion With Human Fetal Liver CD34+ Cells (GenomeWideSNP_6)
Reprogramming of the human fibroblast genome into the state of the hematopoietic progenitors Two samples analyzed.
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-23414 | biostudies-arrayexpress
TranscriptomicsReprogramming of Human Fibroblasts into Hematopoietic Progenitors by Fusion With Human Fetal Liver CD34+ Cells (RNA-Seq)
Reprogramming of the human fibroblast genome into the state of the hematopoietic progenitors One sample analyzed.
ORGANISM(S): Homo sapiens 
2011-08-04 | E-GEOD-23415 | biostudies-arrayexpress
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