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TranscriptomicsEffect of ultradian light-dark cycles on the transcriptome of mice carying a human Per3 polymorphism
In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicit...
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55495 | biostudies-arrayexpress
TranscriptomicsEffect of 12 hour sleep restriction on the transcriptome of mice carying a human Per3 polymorphism
In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicit...
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55494 | biostudies-arrayexpress
TranscriptomicsEffects of dietary curcumin on the colon proteome and transcriptome in the Mdr1a-/- mouse model of inflammatory bowel disease
This study assessed gene expression changes associated with inflammation in the colon tissue of multi-drug resistance targeted mutation (Mdr1a-/-) mice, a model of human IBD. It also tested the anti-inflammatory potential of curcumin in the colon of these mice with a particular focus on the proteome...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61939 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
Background The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited. Here, using a whole genome Mycobacterium tuberculosis microarray to measure cross-genome representation of amplified mRNA populations, we ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-03-12 | E-BUGS-42 | biostudies-arrayexpress
TranscriptomicsReplacing skeletal muscle alpha-actin with cardiac actin in mouse skeletal muscle
Skeletal muscle actin mice (Crawford et al., (2002) Mol Cell Biol 22, 5587) were crossed with cardiac actin transgenic mice (termed "ACTC^Coco" or "Coco" for short), to produce mice that had cardiac actin instead of skeletal muscle actin in their skeletal muscles (termed "AC...
ORGANISM(S): Mus musculus 
2009-05-24 | E-GEOD-12882 | biostudies-arrayexpress
TranscriptomicsEffect of sleep restriction on the human transcriptome during extended wakefulness
In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept awake for a day, a night and the subsequent day. During each of these periods of extended wakefulness 10 blood samples were t...
ORGANISM(S): Homo sapiens 
2013-02-27 | E-GEOD-39445 | biostudies-arrayexpress
UnknownMutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.
Not available
S-EPMC3113346 | biostudies-literature
TranscriptomicsMistimed sleep disrupts circadian regulation of the human blood transcriptome
22 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake cycle and the associated fasting-feeding cycle is scheduled to a 28-hour period, of which one third (i.e. 9h 20min) is schedu...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-48113 | biostudies-arrayexpress
TranscriptomicsA human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-11 | E-GEOD-55255 | biostudies-arrayexpress
UnknownComprehensive genetic diagnosis of tandem repeat expansion disorders with programmable targeted nanopore sequencing.
Not available
S-EPMC8896783 | biostudies-literature
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