Sort   by:  
 Page size 
ProteomicsA Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS), conditions often associated with gut micro...
ORGANISM(S): Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) 
2025-09-28 | PXD059166 | Pride
Chemical proteomics Activity-based protein profiiling Bacteroides fragilis 
ProteomicsChemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness
Serine hydrolases play important roles in signaling and human metabolism, yet little is known about the functions of these enzymes in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 
2023-07-10 | PXD035963 | Pride
Activity-based protein profiling Protease Microbiome 
ProteomicsStructure of Staphylococcus aureus ClpP bound to the covalent active site inhibitor Cystargolide A
The caseinolytic protease is a highly conserved serine protease, seminal in prokaryotic and eukaryotic protein homeostasis and regulatory proteolysis, and a promising antibacterial and anticancer drug target. Here, we describe the cystargolides as potent and the first natural β-lactone inhibitors of...
ORGANISM(S): Staphylococcus aureus 
2023-11-30 | PXD045453 | Pride
Antibacterials Chemmical proteomics Proteases 
Sort   by:  
 Page size