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ProteomicsCCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation
Chemokine receptor CCR6 is a G-protein-coupled receptor that binds its high-affinity ligand, CCL20. Among the CD4+ T cells, Th17 and regulatory T cells express CCR6, which facilitates their migration in CCL20-enriched, inflamed tissue. Migration of CCR6+ T cells from secondary lymphoid tissues into ...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD071790 | Pride
Ccr6  th17 cells  ulcerative colitis  chemokine receptor 
TranscriptomicsTranscription profiling of mouse T cell model to characterize transendothelial migration across lymphatics
Sphingosine 1-phosphate (S1P) influences T cell migration into and out of secondary lymphoid organs; however, its mechanism of action remains uncertain. Our previous research shows that agonism of the S1P receptor S1P1 inhibits the egress of T lymphocytes from the peripheral tissues into afferent ly...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9237 | biostudies-arrayexpress
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