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TranscriptomicsTranscript profiling of Lymphangioleiomyomatosis (LAM) nodules in Human Patients
Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction caused by smooth, muscle-like LAM cells which have mutations in the tumor suppressor genes Tuberous Sclerosis Complex (TSC) 1 or 2, and the capacity to metastasize. Since chemokines and their receptors function in chemotaxis ...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-12027 | biostudies-arrayexpress
TranscriptomicsCD147 and downstream ADAMTSs promote the tumorigenesis of Kaposi sarcoma-associated herpesvirus
The Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi’s Sarcoma (KS), which preferentially arise in immunocompromised patients but lack of effective therapeutic options. We have previously shown that KSHV or viral protein LANA can up...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-69067 | biostudies-arrayexpress
UnknownNeuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes.
Not available
S-EPMC6463921 | biostudies-literature
GenomicsIdentification of Host-Chromosome Binding Sites and Candidate Gene Targets for KSHV LANA
LANA is essential for tethering the KSHV genome to metaphase chromosomes and for modulating host-cell gene expression, but the binding sites in the host-chromosome remain unknown. Here, we use LANA-specific chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to identify ...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-34890 | biostudies-arrayexpress
UnknownHyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling.
Not available
S-EPMC10866655 | biostudies-literature
GenomicsSite-Specific Association with Host and Viral Chromatin by KSHV LANA and its Reversal during Lytic Reactivation
Latency-associated nuclear antigen (LANA), a multifunctional protein expressed by the Kaposi sarcoma-associated herpesvirus (KSHV) in latently-infected cells, is required for stable maintenance of the viral episome. This is mediated by two interactions: LANA binds to specific sequences (LBS1 and 2) ...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-56144 | biostudies-arrayexpress
UnknownInvasive Group B Streptococcus Infections Caused by Hypervirulent Clone of S. agalactiae Sequence Type 283, Hong Kong, China, 20211.
Not available
S-EPMC11682793 | biostudies-literature
GenomicsIdentification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Elg1, the major subunit of a Replication Factor C-like complex, is critical to ensure genomic stability during DNA replication, and is implicated in controlling chromatin structure. We investigated the consequences of Elg1 loss for the dynamics of chromatin re-formation following DNA replication. Me...
ORGANISM(S): Saccharomyces cerevisiae 
2018-10-31 | E-MTAB-6985 | biostudies-arrayexpress
UnknownDirect binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
Not available
S-EPMC2440593 | biostudies-literature
UnknownGenome-wide association study to identify novel loci and genes for Fusarium root rot resistance in sweet potato using genotyping-by-sequencing.
Not available
S-EPMC10584150 | biostudies-literature
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