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ProteomicsPhosphorylation of PABPN1 during mitosis protects mRNA from hyperadenylation and maintains transcriptome stability.
Polyadenylation controls mRNA biogenesis, nuclear export, translation, and decay. These processes are interdependent and coordinately regulated by several poly(A)-binding proteins (PABPs). How PABPs are functionally regulated to control RNA fate is not fully understood. Here, we show that human PABP...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD047110 | Pride
3′ end processing factors  polyadenylation Pabpn1 Rna stability Cell cycle Long-read sequencing 
TranscriptomicsGene expression response to the antifungal compound sampangine in C. albicans
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Candida albicans 
2010-05-26 | E-GEOD-10075 | biostudies-arrayexpress
TranscriptomicsGene expression response to the antifungal compound sampangine
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Candida albicans 
2010-05-26 | E-GEOD-10104 | biostudies-arrayexpress
TranscriptomicsExpression data from DKAT and other breast cancer cell lines under baseline growth conditions
The DKAT cell line is a novel model of triple-negative breast cancer that was isolated from the pleural effusion of a 35 year-old caucasian woman with triple-negative breast cancer. We used microarrays to look at gene expression in the DKAT cell line compared to several other commonly-used breast ca...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-33145 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of HCT-116 versus HCT-116 treated with 5-aza-2'-deoxycytidine processing human colon cancer cell lines
UCRs expression signature of HCT-116 cell lines versus HCT-116 cell line treated with DNA methylation inhibitor 5-aza-2'-deoxycytidine
ORGANISM(S): Homo sapiens 
2010-03-09 | E-MTAB-196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
TranscriptomicsEnoxacin_ColonCancer
We show that the small molecule enoxacin, a fluroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by its binding to the microRNA biosynthesis protein TRBP. The use of enoxacin in human cell cultures and xenografted, orthotopic and metasta...
ORGANISM(S): Mus musculus 
2011-09-24 | E-TABM-1077 | biostudies-arrayexpress
TranscriptomicsArtemisinic Acid Production Stress in Yeast
We have enginereed S. cerevisiae to produce high titers of Artemisinic acid, an anti-malarial drug precursor. Here we compare the gene expression profiles of the producer strain (EPY330) and a strain in which the last enzyme of the pathway (CYP71AV1, AMO) was inactivated by a point mutation (EPY338)...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-15 | E-GEOD-11620 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast recovery after hydrogen peroxide stress
Yeast cells response during recovery after hydrogen peroxide stress. Comparison of yeast cells treated with 1.5mM hydrogen peroxide for 30 min with cells allowed to recover for 60 min
ORGANISM(S): Saccharomyces cerevisiae 
2006-01-28 | E-MEXP-326 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat severed medial collateral ligament following injury
Gene Expression Profiling of Severed Rat Medial Collateral Ligament at 1, 2, 4, 7,1 0, and 14 days Following Injury with Control and Cultured Ligament Fibroblasts and Rat Universal Reference RNA; The aim of this study was to assess the genes involved in the repair of the the dense connective tissue ...
ORGANISM(S): Rattus norvegicus 
2008-04-05 | E-GEOD-10720 | biostudies-arrayexpress
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