Sort   by:  
 Page size 
ProteomicsPABPN1-protein Interactome
Identification of PABPN1 interacting proteins by proximity labeling with TurboID coupled with mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2023-08-04 | PXD039864 | Pride
Hela Ap-ms Pabpn1 
Transcriptomics3'-Seq LK Pabpn1 KD in vivo
Here, we present a 3'-Seq dataset of Pabpn1 KD LK cells and Scr control cells.
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-8538 | biostudies-arrayexpress
TranscriptomicsGenome-wide maps of polyadenylation sites in control and PABPN1kd cells
We applied deep-sequencing based technique, 3'-Seq, to obtain comprehansive maps of poly-A sites in human cells. 3'-Seq was applied to two cell lines (U2OS and RPE-1), in control and PABPN1 knockdown cells Examination of poly-A sites in control and PABPN1kd cells (in two different cell lines)
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-27452 | biostudies-arrayexpress
ProteomicsPhosphorylation of PABPN1 during mitosis protects mRNA from hyperadenylation and maintains transcriptome stability.
Polyadenylation controls mRNA biogenesis, nuclear export, translation, and decay. These processes are interdependent and coordinately regulated by several poly(A)-binding proteins (PABPs). How PABPs are functionally regulated to control RNA fate is not fully understood. Here, we show that human PABP...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD047110 | Pride
3′ end processing factors  polyadenylation Pabpn1 Rna stability Cell cycle Long-read sequencing 
ProteomicsPabpn1-driven cytoskeletal rearrangement induces muscle wasting
Poly(A) binding protein nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing. PABPN1 inhibits alternative polyadenylation (APA), and in conditions with reduced PABPN1 levels APA utilization causes genome-wide mRNA dysregulation. PABPN1 levels decline from midlife onwards in Oculophar...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD004865 | Pride
Pfn1 Pabpn1 Mouse Csrp3 Progenesis Lfq Murc 
ProteomicsNuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break rep
The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks (DSBs). The primary transducer of the DSB response is the protein kinase, ataxia-telangiectasia, mutated (ATM). Here, we establish nuclear poly(A)-binding protein 1 (PABPN1) as a no...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD005913 | Pride
Pabpn1 Mass spectrometry Dna damage response Lc-ms/ms 
GenomicsPABPN1 effect on translation efficiency.
PABPN1 effect on translation efficiency.
PRJNA695208 | ENA
ProteomicsZC3H11A interacts with PABPN1 and alters polyadenylation of viral transcripts
Nuclear mRNA metabolism is regulated by multiple proteins, which either directly bind to RNA or form multi-protein complexes. The RNA-binding protein ZC3H11A is involved in nuclear mRNA export, and NF-κB signaling and is essential during mouse embryo development. Furthermore, previous studies have s...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042238 | Pride
Zinc finger protein Pabpn1 Zc3h11a Adenovirus Polyadenylation 
TranscriptomicsModeling OPMD in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein
Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease caused by an alanine tract expansion mutation in Poly(A)-binding protein nuclear 1 (expPABPN1). To model OPMD in a myogenic and physiological context, we generated mouse myoblast cell clones stably expressing either human wil...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29909 | biostudies-arrayexpress
Genomics3'-Seq LK Pabpn1 KD in vivo
3'-Seq LK Pabpn1 KD in vivo
PRJEB35501 | ENA
Sort   by:  
 Page size