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GenomicsDifferential Gene Expression Upon PFN1 Deletion
Differential Gene Expression Upon PFN1 Deletion
PRJNA630391 | ENA
ProteomicsIP-MS of ALS-linked PFN1 variants
Dominant mutations in profilin-1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by motor neuron loss, paralysis, and death from respiratory failure. Our lab recently demonstrated that PFN1 mutant proteins are destabilized—they unfold a...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD015602 | Pride
Pfn1 Amyotrophic lateral sclerosis Als Diaphanous Profilin 1 Formin 
ProteomicsTMT proteomic analysis of PFN1 iPSC-microglia
To compare the proteome between PFN1 mutant and PFN1 WT iPSC-microglia under baseline conditions
ORGANISM(S): Homo sapiens (Human) 
2024-02-18 | PXD038943 | Pride
Human Als Microglia Profilin 1 
GenomicsExpression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
PRJNA1068499 | ENA
TranscriptomicsDifferential Gene Expression Upon PFN1 Deletion
The actin binding protein profilin1 (PFN1) was deleted using CRISPR/Cas9 in Cath.a differentiated cells.
ORGANISM(S): Mus musculus 
2020-05-06 | GSE149870 | GEO
UnknownDetergent-insoluble PFN1 inoculation expedites disease onset and progression in PFN1 transgenic rats.
Not available
S-EPMC10560758 | biostudies-literature
TranscriptomicsExpression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like c...
ORGANISM(S): Homo sapiens 
2024-01-28 | GSE254069 | GEO
UnknownDetergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats.
Not available
S-EPMC8994973 | biostudies-literature
UnknownPFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
Not available
S-EPMC9600610 | biostudies-literature
UnknownThe Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
Not available
S-EPMC9143529 | biostudies-literature
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