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TranscriptomicsGene expression analysis of Lamin B receptor deficient hematopoietic cells
Gene expression analysis of Lamin B receptor deficient hematopoietic cells
ORGANISM(S): Mus musculus 
2011-12-21 | E-TABM-1134 | biostudies-arrayexpress
TranscriptomicsLamin binding profiles in the ENCODE regions
A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes includ...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24382 | biostudies-arrayexpress
GenomicsRedistribution of the Lamin B1 genomic binding profile affects spatial rearrangement of heterochromatic domains and gene expression during senescence
Senescence is a stress responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lami...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-49341 | biostudies-arrayexpress
TranscriptomicsLamin and Lamin B receptor knockout
influence of lamin B rereceptor knockout and lamin A/C knockout on gene expression in cultured myoblast cells and in striated muscle tissue knockout samples are obtained by mating of heterozygous animals. Homozygous KO and wt animals of one litter are compared. Two boilogical replicates of KO sample...
ORGANISM(S): Mus musculus 
2013-01-28 | E-GEOD-37076 | biostudies-arrayexpress
TranscriptomicsLamin b receptor regulates nuclear architecture and gene expression in olfactory neurons
Gene positioning and regulation of nuclear architecture are thought to influence gene expression. Here, we show that in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes converge in a small number of heterochromatic foci. These foci are OR-exclusive and f...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-38488 | biostudies-arrayexpress
TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
GenomicsHSPB3 promotes myogenic differentiation by targeting the lamin B receptor.
HSPB3 promotes myogenic differentiation by targeting the lamin B receptor.
PRJNA671672 | ENA
TranscriptomicsB-type lamins differentially associate with specific genes during differentiation without directly affecting their expression
B-type lamins, the major structural component of the nuclear lamina, is thought to play a repressive role in the expression of many of its bound genes whose silencing are known to be critical for cell differentiation during early development. Using global mapping of lamin-B-chromatin interaction, w...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-24532 | biostudies-arrayexpress
TranscriptomicsLamin and Lamin B receptor knockout
influence of lamin B rereceptor knockout and lamin A/C knockout on gene expression in cultured myoblast cells and in striated muscle tissue
ORGANISM(S): Mus musculus 
2013-01-28 | GSE37076 | GEO
TranscriptomicsTranscription profiling of mouse wild type cells vs Lmnb1 knockout cells
Comparison of gene expression profiles in wild type cells vs Lmnb1 knockout cells.
ORGANISM(S): Mus musculus 
2007-01-08 | E-MEXP-538 | biostudies-arrayexpress
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