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TranscriptomicsInterplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
We performed integrative methylation, gene dosage and expression profiling to explore the interplay between promoter methylation and loss in gene silencing at 3p11-p14 in cervical cancer. Totally 26 hypermethylated genes were identified by comparing the methylation level of individual CpG sites with...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-68339 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of DCE-MRI and gene expression profiles in construction of a gene classifier for assessment of hypoxia-related risk of chemoradiotherapy failure in cervical cancer
We have previously identified a prognostic 31-gene expression signature in locally advanced cervical cancer that is associated with tumor hypoxia and reflected by the dynamic contrast enhanced magnetic resonance (DCE-MR) image parameter ABrix. To bring the signature closer to clinical use, we here a...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-72723 | biostudies-arrayexpress
TranscriptomicsInterplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
The DNA copy number profiles have previously been uploaded in ArrayExpress (E-MTAB-1161). The previous study included 92 patients, and in the present study the profiles of 75 out of these patients were reused. Absolute copy numbers were calculated using the GeneCount algorithm as described (Lyng et...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-MTAB-3531 | biostudies-arrayexpress
TranscriptomicsMembranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor (EGFR) Predicts Outcome after Chemoradiotherapy of Lymph Node Negative Cervical Cancer
We compared the prognostic significance of ectodomain isoforms of the epidermal growth factor receptor (EGFR), which lack the tyrosine kinase (TK) domain, with that of the full length receptor and its autophosphorylation status in cervical cancers treated with conventional chemoradiotherapy. We furt...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29817 | biostudies-arrayexpress
TranscriptomicsIdentification of eight candidate target genes of the prognsotic 3p loss in cervical cancer by integrative genomic profiling
We performed integrative gene dosage and expression profiling to identify candidate target genes of the prognostic 3p loss in cervical cancer. Candidate target genes were proposed from the correlation between gene dosage and gene expression. Combined network, gene set, and gene ontology analysis of ...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-38964 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast enhanced MRI
We explored the prognostic impact of the dynamic contrast enhanced MR imaging (DCE-MRI) parameter ABrix in cervical cancer combined with global gene expression data to reveal the underlying molecular phenotype of the parameter and construct a gene signature that reflected ABrix. Based on 78 cervical...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-36562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cervical cancer cells to identify genes that showed a correlation between expression and copy number
Microarray experiments were performed to identify genes that showed a correlation between expression and copy number
ORGANISM(S): Homo sapiens 
2009-10-12 | E-TABM-817 | biostudies-arrayexpress
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