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ProteomicsUSP7 is a tumor-specific WNT activator for APC-mutated colorectal cancer by mediating B-catenin deu
The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRC) resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We find tha...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-11-09 | PXD007947 | Pride
Apc Lfq 
ProteomicsNucleocytoplasmic transport and membrane growth control nuclear size
How cells control the overall size of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size that is proportional to cellular size, resulting in a constant ratio between the nuclear and cellular volumes (N/C ratio). To shed light on...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-05 | PXD004530 | Pride
Nuclear cell ratio Nuclear size Silac 
TranscriptomicsMutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
Activating mutations of G protein alpha subunits (Ga) occur in 4-5% of all human cancers1 but oncogenic alterations in beta subunits (Gb) have not been defined. Here we demonstrate that recurrent mutations in the Gb proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G ...
ORGANISM(S): Homo sapiens 
2014-12-07 | E-GEOD-60990 | biostudies-arrayexpress
TranscriptomicsEpidermolysis bullosa associated cutaneous SCC fibroblast expression profiling
Patients with the genetic skin blistering disease recessive dystrophic epidermolysis bullosa (RDEB) develop aggressive cutaneous squamous cell carcinoma (cSCC). Metastasis leading to mortality is greater in RDEB than in other patient groups with cSCC. Here we investigate the dermal component in RDEB...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37738 | biostudies-arrayexpress
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsIn vitro modelling of the human embryo implantation niche
Single-cell RNA-sequencing (10X) data from a three-dimensional cell-engineered system for human implantation that closely recapitulates the cytoarchitecture and physiology of the receptive human endometrium
ORGANISM(S): Homo sapiens 
2024-07-17 | E-MTAB-13629 | biostudies-arrayexpress
UnknownIdentification of common variants associated with human hippocampal and intracranial volumes.
Not available
S-EPMC3635491 | biostudies-literature
UnknownCommon genetic variants influence human subcortical brain structures.
Not available
S-EPMC4393366 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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