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MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
MetabolomicsLipid Profiling of Mouse Intestinal Organoids for studying APC Mutations
Not available
ORGANISM(S): Mus musculus 
ST001707 | MetabolomicsWorkbench
ProteomicsUSP7 is a tumor-specific WNT activator for APC-mutated colorectal cancer by mediating B-catenin deu
The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRC) resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We find tha...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-11-09 | PXD007947 | Pride
Apc Lfq 
TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsRNA Affymetrix microarray analysis of colonic mucosal layer of Apc Min/+ mice fed or not with maslinic acid.
This experiment reports the RNA microarray data from the microarray analysis performed to the RNA isolated from colonic mucosal layer of Apc Min/+ mice. Apc Min/+ mice develop polyps in both the small and large intestine, with a greater incidence of intestinal adenomas observed in the former. We wan...
ORGANISM(S): Mus musculus 
2015-10-31 | E-MTAB-4007 | biostudies-arrayexpress
TranscriptomicsB-catenin deficiency, but not c-Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver
Dysregulated Wnt signalling is seen in approximately 30% of hepatocellular cancers, thus finding pathways downstream of activation of Wnt signalling is key. Using cre lox technology we have deleted the the adenomatous polyposis coli tumour suppressor protein (Apc) within the adult mouse liver and ob...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-65476 | biostudies-arrayexpress
TranscriptomicsThe impact of P53 loss on transcriptome changes following loss of Apc in the intestine
BACKGROUND: p53 is an important tumor suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of thes...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-70262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recom...
ORGANISM(S): Mus musculus 
2006-03-13 | E-TABM-81 | biostudies-arrayexpress
Transcriptomicsin vivo derived apc-mp
Background-The endothelial protein C receptor (EPCR) plays an important role within the protein C (PC) pathway in regulating coagulation and inflammation. Recently, we described a novel mechanism of EPCR release from the surface of primary physiological cells. Induced by exogenous activated protein...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-5661 | biostudies-arrayexpress
TranscriptomicsExpression data for 52 microsatellite stable (MSS) primary tumors from patients with proximal colon cancer.
Samples were taken from surgically resected tumor specimens from patients with proximal colon cancer. The expression profiles were determined using the Affymetrix GeneChip Human Exon 1.0 ST Array version 2. APC gene mutation status was determined using Sanger sequencing. A classifier for APC mutatio...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-63624 | biostudies-arrayexpress
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