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TranscriptomicsMicroarray expression profiling of MAIT subsets isolated from thymus of B6-MAIT/CAST mice, as compared to single positive CD4 or CD8 conventional T cells.
In mice, contrary to conventional T cells, MAIT cells acquire a memory phenotype in the thymus in relation with Zbtb16 expression (Savage et al., 2008 ; Koay et al., 2016). To define phenotypic transcriptional signatures of MAIT subsets in the thymus, we analyzed by microarray the transcriptome of M...
ORGANISM(S): Mus musculus 
2019-07-01 | E-MTAB-7702 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of colon and ileum tissue from naive wild type, MR1-/- and IL-17A-/- mice
Determination of differentially expressed genes in the proximal colon and distal ileum tissue in MR1 and IL-17A deficiency at steady-state. Tissue from naïve mice was harvested, total RNA extracted and subjected to RNASeq analysis.
ORGANISM(S): Mus musculus 
2018-03-31 | E-MTAB-6547 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of metabolite specific T-cells (MR1-restricted) from adult mouse thymus
Mucosal-Associated Invariant T cells (MAIT cells) have a unique specificity for the microbial metabolite 5-OP-RU presented by the non-classical presentation molecule MR1. Upon activation, they release cytotoxic mediators and engage an antimicrobial activity. As a subset of T lymphocytes, MAIT develo...
ORGANISM(S): Mus musculus 
2019-07-01 | E-MTAB-7704 | biostudies-arrayexpress
TranscriptomicsExpression data from healthy human CD161++CD8aa and CD161++CD8ab T cells
We used microarrays to compare gene expression between healthy human CD161++CD8aa and CD161++CD8ab T cells. We sorted freshly obtained peripheral blood mononucleocytes from healthy controls by first using magnetic beads to negatively select for CD8a+ T cells, fluorescently labelling isolated cells w...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33374 | biostudies-arrayexpress
TranscriptomicsExpression data from human cord blood CD161++/CD161+/CD161- CD8+ T cell subsets
We used microarray to compare gene expression between CD161++/CD161+/CD161-CD8+ T cells from human cord blood. Lymphocytes from freshly obtained human cord blood samples were isolated by Ficoll density centrifugation. CD8+ T cells were purified by negative selection using magnetic beads and subseque...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33424 | biostudies-arrayexpress
Genomics8044f1ed-f7ee-42e5-87e3-6506d5746d96 - samples
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite improvement of diagnosis and treatment of the primary tumor, there is no effective treatment of metastatic disease and approximately half of patients will die within one year or less following metastases detecti...
EGAD00001004554 | EGA
GenomicsComprehensive genetic analysis of uveal melanoma heterogeneity during metastatic progression
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite improvement of diagnosis and treatment of the primary tumor, there is no effective treatment of metastatic disease and approximately half of patients will die within one year or less following metastases detecti...
EGAS00001002761 | EGA
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