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TranscriptomicsMutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find novel therapeutic leads for this subgroup of patients, we analyzed 58 blastemal-type Wilms tumors by exome and transcriptome sequ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60081 | biostudies-arrayexpress
ProteomicsPRMT1-mediated methylation of the Large Drosha Complex regulates microRNA biogenesis
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Large Drosha Complex (LDC). Through high resolution mass spectrometry (MS) analysis we discovered that the LDC is extensively methylated, with 82 distinct methylated sites associated...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD011617 | Pride
Prmt1 Large drosha complex Mass spectrometry Microrna Protein methylation 
GenomicsPRMT1 regulates microRNA biogenesis through the methylation of the Large Drosha Complex
PRMT1 regulates microRNA biogenesis through the methylation of the Large Drosha Complex
PRJNA562522 | ENA
TranscriptomicsMicroRNA profiling of wild type and p72 knock-out mice embryos
To examine the effect of DEAD-box RNA helicase subunits on the primary miRNAs processing by Drosha complex, we made knockout mice of p72, DEAD-box RNA helicase, a component of Drosha complex. And we compare the miRNA expression profiles derived from whole mice embryo between wild-type and p72 KO mic...
ORGANISM(S): Mus musculus 
2007-04-12 | E-MEXP-1052 | biostudies-arrayexpress
TranscriptomicsDGCR8 HITS-CLIP reveals novel functions for the Microprocessor (CLIP-seq)
The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. We have used high-throughput sequencing of RNAs isolated by crosslinking immuno...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39086 | biostudies-arrayexpress
TranscriptomicsGene expression data from Wilms tumor samples
Wilms tumor (nephroblastoma) is a pediatric kidney tumor that arises from renal progenitor cells. Since the blastemal type is associated with adverse prognosis, we characterized such Wilms tumors by exome and transcriptome analysis. We detected novel, recurrent somatic mutations affecting the SIX1/2...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-53224 | biostudies-arrayexpress
GenomicsPRMT1 regulates microRNA biogenesis through the methylation of the Large Drosha Complex
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Large Drosha Complex (LDC). We previously reported that the LDC is highly methylated. To investigate the extent of this post-translational modification, we extensively characterized ...
ORGANISM(S): Homo sapiens 
2019-10-23 | GSE136418 | GEO
TranscriptomicsGenome wide identification of targets of the drosha-pasha/DGCR8 complex
Drosha is a type III RNAse, which plays a critical role in miRNA biogenesis. Drosha and its double-stranded RNA-binding partner protein Pasha/DGCR8 likely recognize and cleave miRNA precursor RNAs or pri-miRNA hairpins co-transcriptionally. To identify RNAs processed by Drosha, we used tiling microa...
ORGANISM(S): Drosophila melanogaster 
2008-12-25 | GSE14215 | GEO
TranscriptomicsDGCR8 acts as a novel adaptor for the exosome complex to degrade double-stranded structured RNAs
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggest...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-73376 | biostudies-arrayexpress
UnknownThe evidence for a microRNA product of human DROSHA gene.
Not available
S-EPMC5785223 | biostudies-literature
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