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MetabolomicsLKB1 inactivation elicits a NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where MTA accumulation partially inhibits its activity. However, It remains unclear whether other genetic alterations can dictate PRMT5 activity in can...
2026-04-30 | MTBLS14411 | MetaboLights
ProteomicsIdentification of PRMT1 interaction proteins in cancer and neural stem cells
We have showed that cancer cells (or tumorigenic cells) resemble neural stem/progenitor cells in regulatory network, tumorigenicity and differentiation potential. We have shown PRMT1 is a protein that is upreguated in and promotes vaious cancers. The expression of its gene is localized to embryonic ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-20 | PXD026851 | Pride
Ne-4c Prmt1 Hepg2 Lc-ms/ms 
ProteomicsPRMT1 controls the Senescence Associated Secretory Phenotype in Replication Stress Response
The protein arginine methyltransferase PRMT1 is overexpressed in various human cancers and linked to poor response to therapy. Although various inhibitors targeting its activity are under development, we still do not fully understand how PRMT1 is involved in the cellular processes underpinning tumor...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD014799 | Pride
Prmt1 Sasp Replication stress response Arginine methylation 
TranscriptomicsPRMT1 interacts with leukemia fusion protein AML1-ETO for activation of transcription and transformation
Fusion protein AML1-ETO resulted from t(8;21) translocation is highly related to leukemia development. We have previously shown that the expression of AE9a, a spliced form of AML1-ETO, can rapidly cause leukemia in mouse. To understand how AML1-ETO is involved in leukemia development, we used AE9a l...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-28135 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HeLa cells follwing siRNA mediated knock down of the arginine methyltransferases CARM1 and/or PRMT1
siRNA mediated knockdown of the arginine methyltransferases CARM1 and/or PRMT1 in HeLa cells
ORGANISM(S): Homo sapiens 
2007-08-30 | E-MEXP-1173 | biostudies-arrayexpress
TranscriptomicsTargeting epigenetic networks mediated by Prmt1 and Kdm4c in acute myeloid leukemia
Transcriptional deregulation plays a major role in acute myeloid leukemia, identification of epigenetic modifying enzymes essential for the maintenance of oncogenic transcription programs holds the key to better understanding the biology and designing effective therapeutic strategies for the disease...
ORGANISM(S): Mus musculus 
2016-01-14 | E-MTAB-3322 | biostudies-arrayexpress
ProteomicsPRMT1-mediated methylation regulates MLL2 stability and gene expression
The interplay between multiple transcription factors precisely regulates eukaryotic transcription. Here, we report that the protein methyltransferases, MLL2 and PRMT1, interact directly and act collectively to regulate gene expression. PRMT1 binds to the N-terminal region of MLL2, considered an intr...
ORGANISM(S): Homo Sapiens (human) 
2024-10-21 | PXD055018 | JPOST Repository
ProteomicsOligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma
PRMT1 is the predominant type I protein arginine methyltransferase responsible for generating monomethylarginine and asymmetric dimethylarginine (MMA and ADMA) in various protein substrates. It regulates numerous biological processes, including RNA metabolism, mRNA splicing, DNA damage repair, and c...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061743 |
GenomicsPRMT1 and CSNK1a1 control epidermal progenitor maintanence (PRMT1 ChIP-seq data set)
PRMT1 and CSNK1a1 control epidermal progenitor maintanence (PRMT1 ChIP-seq data set)
PRJNA432778 | ENA
GenomicsPRMT1 suppresses anti-tumor immunity
PRMT1 suppresses anti-tumor immunity
PRJNA840921 | ENA
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