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MetabolomicsEarly postnatal metabolic profile in neonates with different birth weight status: A pilot study

INTRODUCTION: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this ...

2021-04-28 | MTBLS2376 | MetaboLights
ProteomicsHigh-quality and robust protein quantification in large clinical cohort of serum samples with IonStar
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approaches may suffer from substantial batch effects; and...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD036822 | Pride
Large-cohort clinical study  quantitative proteomics  ionstar  liquid chromatography-mass spectrometry  high-resolution mass spectrometry 
MetabolomicsTargeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study

Background. Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, carries a high risk of severe complications. Patients diagnosed with paroxysmal atrial fibrillation (PAF) may progress to persistent atrial fibrillation (PerAF) following a period. We aimed to identify metabo...

2026-07-03 | MTBLS13136 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
ProteomicsA targeted strategy for developing proteomic biomarkers: a case study of epithelial ovarian cancer
Protein biomarkers for epithelial ovarian cancer are critical for the early detection of the cancer to improve patient prognosis and for the clinical management of the disease to monitor treatment response and to detect recurrences. Unfortunately, the discovery of protein biomarkers is hampered by t...
ORGANISM(S): Homo Sapiens 
2019-08-14 | PXD014474 | panorama
ProteomicsEpithelial ovarian cancer biomarker
Protein biomarkers of early stages of disease are critical for managing the disease and improving outcomes. Unfortunately, discovery of protein biomarkers is hampered by the limited availability of assays for sensitive and reproducible quantification of proteins in complex biological matrices such a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-02 | MSV000084048 | MassIVE
TranscriptomicsTranscription profiling of human diagnostic samples from children with NCI high risk B-precursor ALL treated on the protocol COG 1961 to investigate early response and outcome in high-risk childhood acute lymphoblastic leukemia
The cure rate for childhood ALL has improved considerably in part because therapy is routinely tailored to the predicted risk of relapse. Various clinical and laboratory variables are used in current risk-stratification schemes, but many children who fail therapy lack adverse prognostic factors at i...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7440 | biostudies-arrayexpress
ProteomicsA protein-centric glycoproteomic strategy identifies site-specific glycans as robust diagnostic markers for hepatocellular carcinoma
In this study, we achieved the quantitative glycoproteomics analysis of a large cohort of clinical specimens including 100 Hepatocellular carcinoma (HCC) and 100 healthy control human serums by using an integrated platform.
ORGANISM(S): Homo Sapiens (human) 
2026-06-26 | PXD065283 | JPOST Repository
ProteomicsProteomics at large: Discovery and replication of plasma proteomic biomarkers in independent cohorts - Overweight and obese patients of the Weight Management Clinical program of The Ottawa Hospital
Holistic human proteome maps are expected to complement comprehensive profile assessment of health and disease phenotypes. However, methodologies to analyze proteomes in human tissue or body fluid samples at relevant scale and performance are still limited in clinical research. Their deployment and ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD009350 | Pride
Biomarker Plasma association map Overweight Replication Mass spectrometry Proteomics Obesity 
ProteomicsCross-platform clinical proteomics using the Charité open standard for plasma proteomics (OSPP)
Based on large serum and plasma proteome studies, we generate the Charité Open Peptide Standard for Plasma Proteomics (OSPP), an open, versatile peptide internal standard for targeted and untargeted mass spectrometry-based proteomic studies. The OSPP includes 211 concentration-matched stable-isotope...
ORGANISM(S): Homo Sapiens 
PXD083958 |
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