Sort   by:  
 Page size 
TranscriptomicsHuman lung epithelial cells progressed to malignancy through specific oncogenic manipulations
We have developed cdk4/hTERT-immortalized normal human bronchial epithelial cells (HBECs) to study lung cancer pathogenesis. By studying the oncogenic effect of common lung cancer alterations (p53, KRAS, and c-MYC) we demonstrate the ability of this model to characterize the stepwise transformation...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-40828 | biostudies-arrayexpress
TranscriptomicsExpression profiling defines a recurrence signature in lung squamous cell carcinoma
Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is about 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disea...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5123 | biostudies-arrayexpress
TranscriptomicsGene expression profiling classifies lung squamous cell carcinomas with N1 positive lymph nodes
Using gene expression microarrays, we tested whether lung SCCs that have metastasised to loco-regional lymph nodes (N1/2m) are different to those that directly invade and involve local nodes (N1d). Using 22,323 element microarrays, a non-parametric test identified 126 genes/transcripts that discrimi...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-5828 | biostudies-arrayexpress
TranscriptomicsADAM-28: A potential oncogene involved in asbestos-related lung adenocarcinomas
To identify gene expression biomarkers associated with asbestos-related lung adenocarcinoma, we analyzed primary tumour gene expression for a total of 36 primary lung adenocarcinomas on 22,323 element microarrays, comparing 12 patients with lung asbestos body counts above levels associated with urba...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20875 | biostudies-arrayexpress
Sort   by:  
 Page size