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TranscriptomicsTranscription profiling of human newly diagnosed T-ALL patients treated in the Childrens Oncology Group (COG) T-ALL Study 9404
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-14618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL (COG study 9404)
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL patients (COG study 8704)
The clinical and cytogenetic features associated with T-cell acute lymphoblastic leukemia (T-ALL) are not predictive of early treatment failure. Based on the hypothesis that microarrays might identify patients who fail therapy, we used the Affymetrix U133 Plus 2.0 chip and prediction analysis of mic...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14613 | biostudies-arrayexpress
ModelsCD4 T cell signaling
Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse ...
3521 | Cell Collective
UnknownQuantitative Assessment of Early [18F]Sodium Fluoride Positron Emission Tomography/Computed Tomography Response to Treatment in Men With Metastatic Prostate Cancer to Bone.
Not available
S-EPMC5562173 | biostudies-literature
UnknownNasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.
Not available
S-EPMC10788383 | biostudies-literature
GenomicsWhole-Genome Sequencing of Acute Myeloid Leukemia

We used massively parallel sequencing technology to sequence the genomic DNA of tumor cells (leukemic bone marrow) and normal cells (skin biopsy) obtained from patients with Acute Myeloid Leukemia (AML). Patients had either de novo AML (AML with no prior diagnosis of a hematologic disease or expo...

phs000159.v4.p2 | EGA
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
TranscriptomicsEGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-72468 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of a Triple Negative Breast Cancer Patient: Matched Primary Tumor, Normal, Metastasis and Xenograft samples

Breast Cancer Subject Participant ID 700064 (Source Sample names: 6888 and 206). We used massively parallel DNA sequencing technologies to screen entire genomes, in an unbiased manner, for genetic changes associated with tumor growth and metastasis. We describe the complete genome sequence ...

phs000245.v1.p1 | EGA
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