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TranscriptomicsTranscription profiling of rat periovulatory granulosa cells treated with Org 31710 in vitro
Transcriptional effects of Org 31710 in rat periovulatory granulosa cells in vitro
ORGANISM(S): Rattus norvegicus 
2009-10-02 | E-MEXP-1974 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of the human cell cycle in individual unsynchronized cells
Here, we profiled transcription across the cell cycle in single human myxoid liposarcoma cells, without prior synchronization. Flourescence-activated cell sorting was used to infer G1, S or G2/M cell cycle stages after staining cells for DNA content. Single-cell RNA-sequencing was performed accordin...
ORGANISM(S): Homo sapiens 
2017-11-09 | E-MTAB-6142 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of wild type and Pof mutant Drosophila melanogaster females
In Drosophila, two chromosome-wide compensatory systems have been characterized; the dosage compensation system acting on the male X-chromosome and the chromosome specific regulation of genes located on the heterochromatic 4th chromosome. Dosage compensation in Drosophila is accomplished by hypertra...
ORGANISM(S): Drosophila melanogaster 
2012-05-30 | E-GEOD-28513 | biostudies-arrayexpress
MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
TranscriptomicsDPN and Tamoxifen treatments of parathyroid adenoma cells
Stimulation of estrogen receptor beta in PHPT, genetic changes after 24 and 48h of treatments vs. Control Treatment of parathyroid adenomas (4 patients, 4 adenomas) with DPN 24h (4 samples), DPN 48h (4 samples), OHT 24h (4 samples), OHT 48h (4 samples), control 24h (3 samples), control 48h (4 sample...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-37211 | biostudies-arrayexpress
TranscriptomicsExtraction of high-quality epidermal RNA after NH4SCN induced dermo-epidermal separation of 4 mm human skin biopsies
To obtain a separation of the epidermal and dermal compartments in order to examine compartment specific biological mechanisms in the skin we incubated 4 mm human skin punch biopsies in ammonium thiocyanate (NH4SCN). We wanted to test 1) the histological quality of the dermo-epidermal separation obt...
ORGANISM(S): Homo sapiens 
2010-03-03 | E-GEOD-15101 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of M.tuberculosis using RNA-seq indicates WhiB6 repression of dormancy associated genes
Tuberculosis is an infectious disease, with latent infection with Mycobacterium tuberculosis (M.tb) affecting 1/3 of humanity. It can remain quiescent for long time, making eradication very difficult. To do so, M.tb need to carefully orchestrate its gene expression to survive immune response and sta...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2013-09-18 | E-GEOD-40941 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human adrenocortical tumors to identify molecular predictors of diagnosis and prognosis
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 92 samples on Affymetrix HG-U133 Plus 2.0 GeneChips arrays for 92 patients with Adrenocortical Tumors (ACT). 4 normal adrenal samples from the same batch are also include...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-TABM-311 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of RNA associated to the MSL-complex in Drosophila melanogaster
In Drosophila, the global increase in transcription from the X chromosome in males to compensate for its monosomy is mediated by the male-specific-lethal complex (MSL-C) consisting of five proteins and two non-coding RNAs, roX1 and roX2. After an initial sequence dependent recognition by the MSL-C o...
ORGANISM(S): Drosophila melanogaster 
2011-04-13 | E-GEOD-20249 | biostudies-arrayexpress
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