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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsExpanding the cerebrospinal fluid endopeptidome
Biomarkers of neurodegenerative disorders are needed to assist in diagnosis, to monitor disease progression and therapeutic interventions, and to provide insight into disease mechanisms. One route to identify such biomarkers is by proteomic and peptidomic analysis of cerebrospinal fluid (CSF). In t...
ORGANISM(S): Homo sapiens (Human) 
2017-01-17 | PXD004863 | Pride
Peptidomics Alzheimer’s disease Cerebrospinal fluid Peptides Parkinson’s disease Biomarkers Neurodegeneration 
MetabolomicsLarge-scale non-targeted serum metabolomics in the Swedish Twin Registry
The TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. The study participants have previously participated in a telephone interview called Screening Across the Lifespan Twin Study, conducted between 1998 and 2002. To be include...
2014-08-30 | MTBLS93 | MetaboLights
MetabolomicsDisease phenotype prediction in multiple sclerosis

Progressive multiple sclerosis (PMS) is currently diagnosed retrospectively. Here, we work towards a set of biomarkers that could assist in early diagnosis of PMS. A selection of cerebrospinal fluid metabolites (n=15) was shown to differentiate between PMS and its preceding phenotype in an indepe...

2023-05-31 | MTBLS1464 | MetaboLights
ProteomicsProteome characterization of Breast Cancer Cell lines
Protein profiling of 18 breast cancer cell lines in triplicates using TMT10-plex.
ORGANISM(S): Homo Sapiens (human) 
2020-07-04 | PXD013276 | JPOST Repository
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