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TranscriptomicsGene expression analysis of osteosarcoma tumor-initiating cells (High) vs bulk tumor cells (Low)
In the cancer stem cell model a cell hierarchy has been suggested as an explanation for intratumoral heterogeneity, and tumor formation is thought to be driven by this tumor cell subpopulation. The identification of cancer stem cells in osteosarcoma (OS) and the biological processes dysregulated in ...
ORGANISM(S): Homo sapiens 
2011-11-04 | E-GEOD-33458 | biostudies-arrayexpress
TranscriptomicsGenotype profiling of primitive neuroectodermal tumours (250K_Nsp_SNP and 250K_Sty_SNP)
Primitive neuro-ectodermal tumours (PNET) of the supratentorial region are rare, highly malignant embryonal brain tumours affecting young children. Although supratentorial PNET (sPNET) are histologically similar to infratentorial PNET/medulloblastoma, sPNET have more aggressive clinical phenotypes, ...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-14087 | biostudies-arrayexpress
TranscriptomicsGenotype profiling of a primitive neuroectodermal tumour identifies a non-constitutive chr19q13.41 amplicon
Primitive neuro-ectodermal tumours (PNET) of the supratentorial region are rare, highly malignant embryonal brain tumours affecting young children. Although supratentorial PNET (sPNET) are histologically similar to infratentorial PNET/medulloblastoma, sPNET have more aggressive clinical phenotypes, ...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14248 | biostudies-arrayexpress
GenomicsGenotype - samples
PNET genotyping
EGAD00010000260 | EGA
GenomicsMolecular Sub-grouping of CNS-PNET
In our study we aimed to define CNS-PNET subgroups. We performed Expression, Genotyping and/or Immunohistochemistry on 142 samples from 20 worldwide centers. Using these techniques, we have identified three molecular subgroups with distinct expression and copy number patterns, as well as, unique c...
EGAS00000000116 | EGA
GenomicsAnnie Huang and the Hospital for Sick Children
Data Access Committee EGAC01000000015
EGAC01000000015 | EGA
GenomicsThe Genomic Analysis of Medulloblastoma

Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whol...

phs000409.v1.p1 | EGA
TranscriptomicsNovel mutations target distinct subgroups of medulloblastoma.
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. To identify mutations that drive medulloblastoma we sequenced the entire genomes of 37 tumours and matched normal blood. One hundred and thirty-six genes harbouring somatic mutations in this discovery set wer...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-37418 | biostudies-arrayexpress
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownEffects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.
Not available
S-EPMC4284947 | biostudies-literature
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