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TranscriptomicsThe gain-of-function AKT1E17K allele is oncogenic in mouse mammary gland
The gain-of-function mutation in the pleckstrin homology domain of AKT1 (AKT1E17K) occurs in lung and breast cancer. By use of human cellular models and of a AKT1E17K transgenic Cre-inducible murine strain (R26-AKT1E17K mice) we have demonstrated that AKT1E17K is a bona-fide oncogene for lung epithe...
ORGANISM(S): Mus musculus 
2022-06-01 | E-MTAB-7388 | biostudies-arrayexpress
TranscriptomicsPathways regulated by oncogenic PTEN/PI3K/AKT signalling in NSCLC
Hyperactivation of the phosphatydil-inositol-3' phosphate kinase (PI3K)/AKT pathway is observed in most NSCLCs, promoting proliferation, migration, invasion and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mutatio...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5286 | biostudies-arrayexpress
TranscriptomicsAnalysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signalling in lung cancer cells
Hyperactivation of the PI3K/AKT pathway is observed in most NSCLCs, promoting proliferation, migration and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mutations of the catalytic subunit of the positive regulator ...
ORGANISM(S): Homo sapiens 
2016-06-13 | E-MTAB-4263 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of NCI-H460 growth as spheres or in adherent conditions
In this study, we provide evidence that spheroids cells isolated from established human NSCLC cell lines are highly enriched in NSCLC-TICs that aberrant Akt-IL6-Stat3 signalling axis is necessary for self-renewal of lung TICs in vitro and for tumor formation in vivo.
ORGANISM(S): Homo sapiens 
2013-08-06 | E-MTAB-1699 | biostudies-arrayexpress
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