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TranscriptomicsGenomic analysis of hESC pedigrees enables identification of de novo genetic alterations and determination of the timing and origin of mutational events
Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in hiPSCs have shown that deletions and regions of loss-of-heterozygosity (LOH) tend to arise during reprogramm...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49452 | biostudies-arrayexpress
TranscriptomicsFull-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
We assessed Smart-Seq, a new single-cell RNA-Seq library preparation method, on a variety of mouse and human RNA samples or cells. We generated RNA-Seq libraries for dilution series of MAQC reference RNA and mouse brain RNA to assess technical reproducibility, and for a variety of individual cells i...
ORGANISM(S): Homo sapiens 
2012-07-22 | E-GEOD-38495 | biostudies-arrayexpress
TranscriptomicsRegulatory networks define phenotypic classes of human stem cell lines
Stem cells are defined as self-renewing cell populations that can differentiate into multiple distinct cell types. However, hundreds of different human cell lines from embryonic, fetal, and adult sources have been called stem cells, even though they range from pluripotent cells, typified by embryon...
ORGANISM(S): Homo sapiens 
2008-08-25 | E-GEOD-11508 | biostudies-arrayexpress
TranscriptomicsEQUIVALENCE OF CONVENTIONALLY-DERIVED AND PARTHENOTE-DERIVED HUMAN EMBRYONIC STEM CELLS
Parthenote lines proliferated more slowly than conventional hESC lines, and yielded lower quantities of less mature differentiated cells in a neural progenitor cell (NPC) differentiation protocol. However, the cell lines performed similarly in a RPE differentiation protocol. The DNA methylation ana...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-25538 | biostudies-arrayexpress
TranscriptomicsDeriving Dopaminergic Neurons for Clinical Use. A Practical Approach.
Identification of new small molecules that regulate the step-wise differentiation of hPSC into dopaminergic neurons population. Furthermore, the naturally occurring steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. Total RNA extracted...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-42265 | biostudies-arrayexpress
TranscriptomicsRecurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives
This SuperSeries is composed of the following subset Series: GSE30652: Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina HT12v3 Gene Expression] GSE30653: Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and ...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-30654 | biostudies-arrayexpress
TranscriptomicsRecurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 450K DNA Methylation]
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 s...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-31848 | biostudies-arrayexpress
TranscriptomicsRecurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 27K DNA Methylation]
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 s...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-30653 | biostudies-arrayexpress
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