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MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
ProteomicsNidogen-1 is a novel extracellular ligand for the NKp44 activating receptor
The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activati...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008252 | Pride
Nid1 nk nkp44 receptor 
ProteomicsProteomic analysis of cerebrospinal fluid in a Retinoblastoma patient.
This study focuses on the proteomic analysis of cerebrospinal fluid (CSF) in a patient with stage III retinoblastoma (RB) with the aim to identify molecular changes associated with central nervous system (CNS) relapse. The child received systemic chemotherapy and intrathecal topotecan as CNS prophyl...
ORGANISM(S): Homo sapiens (Human) 
2025-04-16 | PXD056783 | Pride
Retinoblastoma Cerebrospinal fluid (csf) Proteomic analysis Case report Liquid biopsy 
ProteomicsMulti-Omics Analysis of PBMCs Highlights IRF8 Upregulation and Senescence Pathways in Hemodialysis Versus Peritoneal Dialysis.
Although the clinical differences between hemodialysis (HD) and peritoneal dialysis (PD) are well described, the specific biological mechanisms that cause these differences remain a subject of ongoing research. Omics-based approaches may help to elucidate these differences. To address this aim, we p...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076533 | Pride
Chronic kidney disease Proteomics Peritoneal dialysis Hemodialysis Cellular senescence Irf8  
ProteomicsLupus Nephritis is characterized by defective removal of Neutrophil Extracellular Traps that are modified in protein composition and contain specific auto-antigens.
Neutrophyl Extracellular Traps (NETs) accumulated in serum of patients with Lupus Nephritis for defective removal by DNAse. Among a complex protein panel (overall 802) two clusters of 16 and 13 proteins were more expressed by LN and SLE NETs respectively; oxidized aenolase and annexin A1 were main c...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD007754 | Pride
Human Proteomics Lupus nephritis Lc-ms/ms 
TranscriptomicsStarvation and chemotherapy
Tumor chemoresistance is often associated to high aerobic glycolysis rates and reduced oxidative phosphorylation by cancer cells, a phenomenon called the “Warburg effect”. Thus, a treatment reversing the Warburg effect could decrease tumor cell survival both in the presence or absence of chemothera...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-60653 | biostudies-arrayexpress
UnknownProteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding.
Not available
S-EPMC7352325 | biostudies-literature
UnknownDevelopment of an Accurate Mass Retention Time Database for Untargeted Metabolomic Analysis and Its Application to Plasma and Urine Pediatric Samples.
Not available
S-EPMC8303579 | biostudies-literature
UnknownFrom hundreds to thousands: Widening the normal human Urinome.
Not available
S-EPMC4459867 | biostudies-literature
UnknownProteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma.
Not available
S-EPMC9659039 | biostudies-literature
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