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TranscriptomicsRNAi knock down of RET finger protein/ Tripartite protein in human osteosarcoma cell lines and analysis of Retinoblastoma protein dependent transcriptional changes
Analysis of Retinoblastoma protein (Rb) (Hs.408528) dependent transcriptional changes following siRNA mediated ablation of the RET finger protein/ Tripartite protein (RFP/TRIM27) (Hs.440382). Common reference design, two biological replicates with two technical replicates each.
ORGANISM(S): Homo sapiens 
2005-06-02 | E-MEXP-278 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of retinoblastoma samples
RNA-seq analysis of five retinoblastoma tumor samples to compare expression signature with retinal organoids generated from hESCs in vitro and modelling retinoblastoma
ORGANISM(S): Homo sapiens 
2022-05-10 | E-MTAB-10330 | biostudies-arrayexpress
ProteomicsProteomic profiling of retinoblastoma by high resolution mass spectrometry
We performed a high throughput comparative proteomics study to identify differentially expressed proteins that could serve as putative targets in retinoblastoma. We used iTRAQ based quantitative proteomics approach and analyzed the samples on orbitrap velos mass spectrometer. We identified and quant...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD002774 | Pride
Quantitative proteomics Retina Cancer Mass spectrometry Retinoblastoma Itraq 
TranscriptomicsGene Expression profiles in Retinoblastoma
Gene expression profiles in retinoblastoma by whole Human Genome DNA microarrays in comparison to the normal retina gave an insight into several genes and pathways that were regulated in the tumor. The upregulated and the downregulated genes were further validated by quantitative real time PCR and ...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-33048 | biostudies-arrayexpress
TranscriptomicsExpression of PRAME in retinoblastoma primary tumors
Transcriptome analysis of partially degraded and fragmented RNA samples from retinoblastoma primary tumors. Global gene expression profiling has shown great promise in high-throughput biomarker discovery for early disease detection in Retinoblastoma tumors. In this analysis we have used 3 retinobla...
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-24673 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA expression profiles in Retinoblastoma serum
Retinoblastoma (RB) is a malignant intraocular neoplasm occurs mostly in children. The malignancy caused due to altered miRNA expression in cancer tumors and circulating body fluids has been reported in several cancers. The aberrantly expressed microRNAs are useful for diagnosis and prognosticating ...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41321 | biostudies-arrayexpress
GenomicSequencing of Retinoblastoma

Retinoblastoma is a pediatric cancer of the developing retina. All retinoblastomas are believed to initiate with biallelic inactivation of the RB1 gene. To identify subsequent genetic lesions in retinoblastoma, we performed whole genome sequencing of tumor and normal DNA of 4 children with retino...

phs000352 | dbGaP
TranscriptomicsDifferential gene expression profile of y79 retinoblastoma cells in response to stress conditions
The Y79 retinoblastoma cells were exposed to oxidative stress conditions with hydrogen peroxide exposure. The differential gene expression profile on this condition was evaluated by comparing with untreated control Y79 cells. The cellular responses based on the differential gene expression was studi...
ORGANISM(S): Homo sapiens 
2011-03-11 | E-GEOD-27880 | biostudies-arrayexpress
GenomicsCopy number profiling of primary samples and cell lines of retinoblastoma
Illumina SNP-arrays for matching retinoblastoma-blood pairs and retinoblastoma cell lines.
EGAD00010000908 | EGA
ProteomicsQUANTITATIVE PHOSPHOPROTEOMIC PROFILING OF PRIMARY RETINOBLASTOMA TUMORS
Retinoblastoma is a malignant tumor of the retina which most often occurs in children below 5 years of age with an incident rate of about 1 in 15,000 to 18,000 live births. Retinoblastoma is the first ever cancer that was reported to have a genetic basis. It occurs widely due to inactivating mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD007228 | Pride
Retinoblastoma Lc-ms Phosphoproteomics 
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