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TranscriptomicsTranscription Factor Substitution during the Evolution of Fungal Ribosome Regulation
Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, i...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-10622 | biostudies-arrayexpress
TranscriptomicsExperimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high resolution tiling arrays
Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation. Here we have undertaken a genome-wide experimental annotation to accurately...
ORGANISM(S): Candida albicans 
2010-07-07 | E-GEOD-22625 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Substitution during the Evolution of Fungal Ribosome Regulation_expression profiling
Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, i...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-10499 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of EJC depletion by RNA-Seq using the SOLiD platform (Applied Biosystems)
Signaling pathways are controlled by a vast array of post-translational mechanisms. By contrast, little is known regarding the mechanisms that regulate the expression of their core components. We conducted an RNAi screen in Drosophila for factors modulating RAS/MAPK signaling and identified the Exon...
ORGANISM(S): Drosophila melanogaster 
2010-10-19 | E-GEOD-24012 | biostudies-arrayexpress
TranscriptomicsA toolbox for epitope-tagging and genome-wide location analysis in Candida albicans
Background : Candida albicans is a diploid pathogenic fungus not yet amenable to routine genetic investigations. Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing...
ORGANISM(S): Candida albicans 
2010-05-16 | E-GEOD-13427 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Substitution during the Evolution of Fungal Ribosome Regulation_ChIP-CHIP
Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, i...
ORGANISM(S): Candida albicans 
2010-05-25 | E-GEOD-10458 | biostudies-arrayexpress
ProteomicsPosternak_PROTACdegradation_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E. This dataset provides a proteome-wide view of protein degradation after treatment...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-10 | MSV000085271 | MassIVE
ProteomicsPosternak_PROTACagainstBRAFV600E_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-07 | MSV000084551 | MassIVE
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