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GenomicsCore transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33850 | biostudies-arrayexpress
GenomicsTranscription factor ChIP-seq in expanded human hematopoietic stem and progenitor cells
While many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models ...
ORGANISM(S): Homo sapiens 
2011-01-26 | E-GEOD-26014 | biostudies-arrayexpress
TranscriptomicsExpression and ChIP-chip data from REH and SEM leukemia cell lines
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aber...
ORGANISM(S): Homo sapiens 
2008-12-14 | E-GEOD-13313 | biostudies-arrayexpress
UnknownGenetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Not available
S-EPMC3431328 | biostudies-literature
UnknownLong-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study.
Not available
S-EPMC6429636 | biostudies-literature
UnknownEffect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study.
Not available
S-EPMC8669534 | biostudies-literature
UnknownThe Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures.
Not available
S-EPMC7783946 | biostudies-literature
UnknownSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).
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S-EPMC12451849 | biostudies-literature
UnknownDetermining crystal structures through crowdsourcing and coursework.
Not available
S-EPMC5028414 | biostudies-literature
UnknownThe 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS).
Not available
S-EPMC9494851 | biostudies-literature
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