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TranscriptomicsRNA-seq profiling of the bovine cervix at 6 timepoints during the peri-oestrus period.
The estrous cycles of Limousin heifers (n = 30) were synchronized by insertion of a controlled internal drug release (CIDR) device (1.94 g progesterone; Pfizer Animal Health) placed into the vagina for 8 days. A 0.5 mg intramuscular injection of a prostaglandin F2α (PG) analogue (PG, Estrumate, Sher...
ORGANISM(S): Bos taurus 
2013-01-04 | E-GEOD-38225 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Coxiella burnetii reveals extensive cell wall remodeling in the small cell variant developmental form
A hallmark of Coxiella burnetii, the bacterial cause of human Q fever, is a biphasic developmental cycle that generates biologically, ultrastructurally, and compositionally distinct large cell variant (LCV) and small cell variant (SCV) forms. LCVs are replicating, exponential phase forms while SCVs ...
ORGANISM(S): Coxiella burnetii 
2016-02-10 | E-GEOD-74489 | biostudies-arrayexpress
TranscriptomicsEvidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau
The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of...
ORGANISM(S): Bos taurus 
2014-04-01 | E-GEOD-56392 | biostudies-arrayexpress
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
MetabolomicsMetabolomics-derived insights into the manipulation of terpenoid sysnthesis in Centella asiatica cells by methyl-jasmonate
Centella asiatica is an important medicinal plant with a wide range of bioactivities associated with its secondary metabolites. Using two extraction procedures, metabolomic approaches were used to investigate changes in the metabolome of C. asiatica cells treated with exogenous MeJA. GC–MS and LC–MS...
2015-03-03 | MTBLS175 | MetaboLights
TranscriptomicsGenetic toxicology and toxicogenomic analysis of 3 cigarette smoke condensates in vitro reveals few differences between high and low tar brands
This experiment investigated the response of mouse pulmonary epithelial cells in culture (FE1 cell line) to 3 different brands of cigarette smoke condensate. The three brands represent a full flavour, regular and king-size light cigarettes. These vary in some key chemical consistuents. Brand #1 has ...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-30079 | biostudies-arrayexpress
MetabolomicsSimilar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza...
2018-10-17 | MTBLS559 | MetaboLights
TranscriptomicsRNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation
Successful establishment and maintenance of pregnancy can be attained only through optimum conceptus-maternal cross talk. Despite significant progress in our understanding of the temporal changes in the transcriptome of the uterine endometrium, we have only a rudimentary knowledge of the genes and p...
ORGANISM(S): Bos taurus 
2014-04-04 | E-GEOD-56513 | biostudies-arrayexpress
TranscriptomicsEffects of Intramuscular Administration of Folic Acid and Vitamin B12 on Granulosa Cells Gene Expression in Postpartum Dairy Cow
The fertility of dairy cows is challenged during early lactation and better nutritional strategies need to be developed to address this issue. Combined supplementation of folic acid and vitamin B12 improves energy metabolism in the dairy cow during early lactation. Therefore, the present study was u...
ORGANISM(S): Bos taurus 
2015-09-15 | E-GEOD-72038 | biostudies-arrayexpress
TranscriptomicsA Global View of the Oncogenic Landscape in Nasopharyngeal Carcinoma:An Integrated Analysis at the Genetic and Expression Levels
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit both recurrent chromosome abnormalities and changes in the expression of numerous genes. However, it is not known to what extent changes in the copy number of individual genes are associated with the obser...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-34573 | biostudies-arrayexpress
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