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ProteomicsPP2A inhibition instructs spliceosome phosphorylation patterns to create splicing vulnerability in colon adenocarcinoma
Protein phosphatase 2A (PP2A) is a promiscuous enzyme that acts on many aspects of cellular physiology. It remains unclear however, which of the cellular processes are most perturbed upon inhibition of PP2A and how such perturbations could be exploited therapeutically. Here, we report an unanticipat...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043658 | Pride
Pp2a inhibition Lb-100 Phosphorylation Colon adenocarcinoma Alternative splicing 
ClinicalLB-100 (PP2A Inhibitor) and Azenosertib (WEE1 Inhibitor) in Metastatic Colorectal Cancer Patients
This Phase Ib trial studies the side effects and best dose of LB-100 and azenosertib for the treatment of patients with metastatic colorectal cancer. Azenosertib blocks a protein that is involved in the repair of damaged DNA, this protein is called WEE1. Inhibiting WEE1 drives cancer cells into a st...
116295 | ecrin-mdr-crc
ClinicalLB-100 (PP2A Inhibitor) and Atezolizumab (PD-L1 Inhibitor) in Metastatic Colorectal Cancer Patients
This Phase Ib trial studies the side effects and best dose of LB-100 when given with atezolizumab for the treatment of patients with metastatic microsatellite stable colorectal cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer...
71807 | ecrin-mdr-crc
GenomicsStaphylococcus aureus strain:J46-100 | breed:LB
Staphylococcus aureus strain:J46-100 | breed:LB Raw sequence reads
PRJNA550358 | ENA
GenomicsPseudomonas aeruginosa strain:P1-100 | breed:LB
Pseudomonas aeruginosa strain:P1-100 | breed:LB Raw sequence reads
PRJNA550363 | ENA
UnknownPhosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
Not available
S-EPMC8262325 | biostudies-literature
UnknownInhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma.
Not available
S-EPMC7017120 | biostudies-literature
UnknownThe phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.
Not available
S-EPMC11094086 | biostudies-literature
UnknownInhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma.
Not available
S-EPMC7467059 | biostudies-literature
UnknownLB-100 Enhances Drugs Efficacy Through Inhibition of P-Glycoprotein Expression in Multidrug-Resistant Glioblastoma and Non-Small Cell Lung Carcinoma Cellular Models.
Not available
S-EPMC11859366 | biostudies-literature
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